Mesalamine Rectal

102 interactions 274 cited references

Also sold as: Canasa Canasa® Rowasa® sfRowasa®

About Mesalamine Rectal

Rectal mesalamine is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum), proctitis (swelling in the rectum), and proctosigmoiditis (swelling in the rectum and sigmoid colon [last section of the colon]). Rectal mesalamine is in a class o… Read the full Mesalamine Rectal drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Probenecid Aceclofenac Acemetacin Amtolmetin Guacil Azathioprine Balsalazide

1 Contraindicated 77 Major 24 Moderate

All (102) Contraindicated (1) Major (77) Moderate (24)

Contraindicated

Mesalamine Rectal Probenecid Salicylates antagonize the uricosuric effects of probenecid Details

Major

Mesalamine Rectal Aceclofenac Increased risk of bleeding Details Mesalamine Rectal Acemetacin Increased risk of bleeding Details Mesalamine Rectal Amtolmetin Guacil Increased risk of bleeding Details Mesalamine Rectal Azathioprine Azasan An increased risk of myelosuppression, an increased risk of hepatotoxicity and an increased risk of blood disorders Details Mesalamine Rectal Balsalazide Colazal Increased risk of bleeding Details Mesalamine Rectal Bismuth Subsalicylate Bismarex Increased risk of bleeding Details Mesalamine Rectal Bromfenac Bromsite Increased risk of bleeding Details Mesalamine Rectal Bufexamac Increased risk of bleeding Details Mesalamine Rectal Celecoxib Celebrex An increased risk of GI toxicity and an increased risk of bleeding Details Mesalamine Rectal Choline Magnesium Trisalicylate Trilisate® Increased risk of bleeding Details Mesalamine Rectal Choline Salicylate Increased risk of bleeding Details Mesalamine Rectal Clonixin Increased risk of bleeding Details Mesalamine Rectal Dexibuprofen Increased risk of bleeding Details Mesalamine Rectal Dexketoprofen Increased risk of bleeding Details Mesalamine Rectal Diclofenac Aleve Arthritis Pain Increased risk of bleeding Details Mesalamine Rectal Diflunisal Dolobid Increased risk of bleeding Details Mesalamine Rectal Dipyrone Increased risk of bleeding Details Mesalamine Rectal Droxicam Increased risk of bleeding Details Mesalamine Rectal Etodolac Lodine Increased risk of bleeding Details Mesalamine Rectal Etofenamate Increased risk of bleeding Details Mesalamine Rectal Etoricoxib Increased risk of bleeding Details Mesalamine Rectal Felbinac Increased risk of bleeding Details Mesalamine Rectal Fenoprofen Fenopron Increased risk of bleeding Details Mesalamine Rectal Fepradinol Increased risk of bleeding Details Mesalamine Rectal Feprazone Increased risk of bleeding Details Mesalamine Rectal Floctafenine Increased risk of bleeding Details Mesalamine Rectal Flufenamic Acid Increased risk of bleeding Details Mesalamine Rectal Flurbiprofen Ansaid Increased risk of bleeding Details Mesalamine Rectal Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity Details Mesalamine Rectal Hydrocortisone Ala-Cort An increased risk of gastrointestinal adverse reactions, reduced salicylate exposure and an increased risk of salicylate toxicity... Details Mesalamine Rectal Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Mesalamine Rectal Indomethacin Indocin Increased risk of bleeding Details Mesalamine Rectal Insulin Icodec-Abae Awiqli An increased risk of hypoglycemia Details Mesalamine Rectal Ketoprofen Actron® Increased risk of bleeding Details Mesalamine Rectal Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Mesalamine Rectal Lornoxicam Increased risk of bleeding Details Mesalamine Rectal Loxoprofen Increased risk of bleeding Details Mesalamine Rectal Lumiracoxib Increased risk of bleeding Details Mesalamine Rectal Magnesium Salicylate Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.