Mesalamine Rectal

Name: Mesalamine Rectal Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

102 interactions 274 cited references

Also sold as: Canasa Canasa® Rowasa® sfRowasa®

About Mesalamine Rectal

Rectal mesalamine is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum), proctitis (swelling in the rectum), and proctosigmoiditis (swelling in the rectum and sigmoid colon [last section of the colon]). Rectal mesalamine is in a class o… Read the full Mesalamine Rectal drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Probenecid Aceclofenac Acemetacin Amtolmetin Guacil Azathioprine Balsalazide

1 Contraindicated 77 Major 24 Moderate

All (102) Contraindicated (1) Major (77) Moderate (24)

Contraindicated

Mesalamine Rectal Probenecid Salicylates antagonize the uricosuric effects of probenecid Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.