Mesalamine Rectal

102 interactions 274 cited references
Also sold as: Canasa Canasa® Rowasa® sfRowasa®
About Mesalamine Rectal

Rectal mesalamine is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum), proctitis (swelling in the rectum), and proctosigmoiditis (swelling in the rectum and sigmoid colon [last section of the colon]). Rectal mesalamine is in a class o… Read the full Mesalamine Rectal drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Probenecid Aceclofenac Acemetacin Amtolmetin Guacil Azathioprine Balsalazide
1 Contraindicated 77 Major 24 Moderate
All (102) Contraindicated (1) Major (77) Moderate (24)

Major

Mesalamine Rectal Meclofenamate Meclodium® Increased risk of bleeding Details Mesalamine Rectal Mefenamic Acid Ponstel® Increased risk of bleeding Details Mesalamine Rectal Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Mesalamine Rectal Mercaptopurine Purinethol® An increased risk of myelosuppression, an increased risk of hepatotoxicity and an increased risk of blood disorders Details Mesalamine Rectal Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Mesalamine Rectal Morniflumate Increased risk of bleeding Details Mesalamine Rectal Nabumetone Relafen Increased risk of bleeding Details Mesalamine Rectal Naproxen Aleve Increased risk of bleeding Details Mesalamine Rectal Nepafenac Ilevro Increased risk of bleeding Details Mesalamine Rectal Niflumic Acid Increased risk of bleeding Details Mesalamine Rectal Nimesulide Increased risk of bleeding Details Mesalamine Rectal Nimesulide Beta Cyclodextrin Increased risk of bleeding Details Mesalamine Rectal Olsalazine Dipentum Increased risk of bleeding Details Mesalamine Rectal Oxaprozin Coxanto Increased risk of bleeding Details Mesalamine Rectal Oxyphenbutazone Increased risk of bleeding Details Mesalamine Rectal Parecoxib Increased risk of bleeding Details Mesalamine Rectal Phenylbutazone Equi-Phar Increased risk of bleeding Details Mesalamine Rectal Phenyl Salicylate Increased risk of bleeding Details Mesalamine Rectal Phenytoin Dilantin Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity Details Mesalamine Rectal Piketoprofen Increased risk of bleeding Details Mesalamine Rectal Piroxicam Feldene Increased risk of bleeding Details Mesalamine Rectal Proglumetacin Increased risk of bleeding Details Mesalamine Rectal Propyphenazone Increased risk of bleeding Details Mesalamine Rectal Proquazone Increased risk of bleeding Details Mesalamine Rectal Rofecoxib Increased risk of bleeding Details Mesalamine Rectal Salicylamide Increased risk of bleeding Details Mesalamine Rectal Salicylic Acid Increased risk of bleeding Details Mesalamine Rectal Salsalate Disalcid Increased risk of bleeding Details Mesalamine Rectal Sodium Salicylate Increased risk of bleeding Details Mesalamine Rectal Sulfasalazine Azulfidine Increased risk of bleeding Details Mesalamine Rectal Sulindac Clinoril® Increased risk of bleeding Details Mesalamine Rectal Tenoxicam Increased risk of bleeding Details Mesalamine Rectal Tiaprofenic Acid Increased risk of bleeding Details Mesalamine Rectal Tolfenamic Acid Increased risk of bleeding Details Mesalamine Rectal Tolmetin Tolectin 600 Increased risk of bleeding Details Mesalamine Rectal Trolamine Salicylate Increased risk of bleeding Details Mesalamine Rectal Valdecoxib Increased risk of bleeding Details Mesalamine Rectal Varicella Virus Vaccine, Live Increased risk of developing Reye syndrome Details

Moderate

Mesalamine Rectal Aluminum Carbonate, Basic Alteration of mesalamine bioavailability Details Mesalamine Rectal Aluminum Hydroxide AlternaGEL® Alteration of mesalamine bioavailability Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.