Mesalamine Rectal

102 interactions 274 cited references
Also sold as: Canasa Canasa® Rowasa® sfRowasa®
About Mesalamine Rectal

Rectal mesalamine is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum), proctitis (swelling in the rectum), and proctosigmoiditis (swelling in the rectum and sigmoid colon [last section of the colon]). Rectal mesalamine is in a class o… Read the full Mesalamine Rectal drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Probenecid Aceclofenac Acemetacin Amtolmetin Guacil Azathioprine Balsalazide
1 Contraindicated 77 Major 24 Moderate
All (102) Contraindicated (1) Major (77) Moderate (24)

Moderate

Mesalamine Rectal Aluminum Phosphate Alteration of mesalamine bioavailability Details Mesalamine Rectal Dihydroxyaluminum Aminoacetate Alteration of mesalamine bioavailability Details Mesalamine Rectal Dihydroxyaluminum Sodium Carbonate Alteration of mesalamine bioavailability Details Mesalamine Rectal Furosemide Disal An increased risk of salicylate toxicity Details Mesalamine Rectal Insulin Afrezza Increased risk of hypoglycemia Details Mesalamine Rectal Insulin Aspart, Recombinant Fiasp Increased risk of hypoglycemia Details Mesalamine Rectal Insulin Bovine Increased risk of hypoglycemia Details Mesalamine Rectal Insulin Degludec Tresiba Increased risk of hypoglycemia Details Mesalamine Rectal Insulin Detemir Levemir Increased risk of hypoglycemia Details Mesalamine Rectal Insulin Glargine, Recombinant Basaglar Increased risk of hypoglycemia Details Mesalamine Rectal Insulin Glulisine Apidra Increased risk of hypoglycemia Details Mesalamine Rectal Insulin Lispro, Recombinant Admelog Increased risk of hypoglycemia Details Mesalamine Rectal Magaldrate Alteration of mesalamine bioavailability Details Mesalamine Rectal Magnesium Carbonate Alteration of mesalamine bioavailability Details Mesalamine Rectal Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Alteration of mesalamine bioavailability Details Mesalamine Rectal Magnesium Oxide Mag-Ox 400 Alteration of mesalamine bioavailability Details Mesalamine Rectal Magnesium Trisilicate Alteration of mesalamine bioavailability Details Mesalamine Rectal Pramlintide Symlin Increased risk of hypoglycemia Details Mesalamine Rectal Tamarind Increased salicylate toxicity Details Mesalamine Rectal Tan-Shen Increased free salicylate serum concentration and decreased tan-shen (Danshen) concentration Details Mesalamine Rectal Thioguanine Tabloid An increased risk of myelosuppression Details Mesalamine Rectal Warfarin Coumadin Decreased warfarin efficacy Details

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