Metformin

378 interactions 1 explained in plain English 428 cited references
Also sold as: Fortamet® Glucophage Glucophage® Glumetza Glumetza® Riomet Riomet® Trijardy® (as a combination product containing Empagliflozin, Linagliptin, Metformin)
About Metformin

Metformin is a biguanide medication used to help control blood sugar levels in type 2 diabetes. Read the full Metformin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ofloxacin Otic Ciprofloxacin Cimetidine Arimoclomol Insulin Glulisine (Rdna Origin) Injection Digoxin
99 Major 278 Moderate 1 Minor
All (378) Major (99) Moderate (278) Minor (1)

Major

Metformin Givinostat Duvyzat Increased metFORMIN exposure and an increased risk of lactic acidosis Details Metformin Grepafloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Metformin Insulin Afrezza An increased risk of hypoglycemia Details Metformin Insulin Aspart, Recombinant Fiasp An increased risk of hypoglycemia Details Metformin Insulin Bovine An increased risk of hypoglycemia Details Metformin Insulin Degludec Tresiba An increased risk of hypoglycemia Details Metformin Insulin Detemir Levemir An increased risk of hypoglycemia Details Metformin Insulin Glargine, Recombinant Basaglar An increased risk of hypoglycemia Details Metformin Insulin Glulisine Apidra An increased risk of hypoglycemia Details Metformin Insulin Icodec-Abae Awiqli An increased risk of hypoglycemia Details Metformin Insulin Lispro, Recombinant Admelog An increased risk of hypoglycemia Details Metformin Iodipamide Increased risk of acute decrease in renal function and occurrence of lactic acidosis Details Metformin Iodixanol Increased risk of acute decrease in renal function and occurrence of lactic acidosis Details Metformin Iohexol Increased risk of acute decrease in renal function and occurrence of lactic acidosis Details Metformin Iomeprol Increased risk of metFORMIN-induced lactic acidosis Details Metformin Iopamidol Increased risk of acute decrease in renal function and occurrence of lactic acidosis Details Metformin Iopanoic Acid Increased risk of acute decrease in renal function and occurrence of lactic acidosis Details Metformin Iopromide Increased risk of acute decrease in renal function and occurrence of lactic acidosis Details Metformin Iothalamate Increased risk of acute decrease in renal function and occurrence of lactic acidosis Details Metformin Iotrolan Increased risk of acute decrease in renal function and occurrence of lactic acidosis Details Metformin Ioversol Increased risk of acute decrease in renal function and occurrence of lactic acidosis Details Metformin Ioxaglate Increased risk of acute decrease in renal function and occurrence of lactic acidosis Details Metformin Ipodate Increased risk of acute decrease in renal function and occurrence of lactic acidosis Details Metformin Isavuconazole Increased metFORMIN exposure and an increased risk of lactic acidosis Details Metformin Isavuconazonium Cresemba Increased metFORMIN exposure and an increased risk of lactic acidosis Details Metformin Lanreotide Acetate An increased risk of hypoglycemia and impaired glucose regulation Details Metformin Levoketoconazole Recorlev Increased metFORMIN exposure and an increased risk of metFORMIN-related adverse effects Details Metformin Lomefloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Metformin Mavorixafor Xolremdi Reduced metFORMIN exposure and reduced efficacy of metFORMIN Details Metformin Methazolamide Neptazane® An increased risk of lactic acidosis and reduced serum bicarbonate Details Metformin Metrizamide Increased risk of acute decrease in renal function and occurrence of lactic acidosis Details Metformin Moxifloxacin Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Metformin Norfloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Metformin Octreotide Acetate An increased risk of hypoglycemia and impaired glucose regulation Details Metformin Ofloxacin Floxin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Metformin Ombitasvir Increased risk of lactic acidosis Details Metformin Paritaprevir Increased risk of lactic acidosis Details Metformin Pasireotide Diaspartate An increased risk of hypoglycemia and impaired glucose regulation Details Metformin Pramlintide Symlin An increased risk of hypoglycemia Details Metformin Pyrimethamine Increased metFORMIN exposure and an increased risk of lactic acidosis Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.