Metformin

Major

Metformin Abemaciclib Verzenio Increased metFORMIN exposure and an increased risk of lactic acidosis Details Metformin Acetazolamide Diamox® Sequels® An increased risk of lactic acidosis and reduced serum bicarbonate Details Metformin Abiraterone Abirtega An increased risk of severe hypoglycemia Details Metformin Arimoclomol Increased OCT2 substrate exposure Details Metformin Brinzolamide Ophthalmic Azopt An increased risk of lactic acidosis and reduced serum bicarbonate Details Metformin Capmatinib Tabrecta Increased exposure of MATE1 and MATE2K substrates and risk of increased adverse reactions Details Metformin Chloroquine Aralen® Hypoglycemia Details Metformin Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Metformin Delafloxacin Injection Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Metformin Digoxin Cardoxin® Increased digoxin exposure Details Metformin Dofetilide Tikosyn Increased dofetilide exposure and an increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Metformin Dolutegravir Juluca® (as a combination product containing dolutegravir, rilpivirine) Increased metFORMIN exposure and an increased risk of lactic acidosis Details Metformin Dorzolamide Ophthalmic Trusopt® Ocumeter® Plus An increased risk of lactic acidosis and reduced serum bicarbonate Details Metformin Gatifloxacin Ophthalmic Zymar® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Metformin Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Metformin Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Metformin Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Metformin Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Metformin Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Metformin Iomeprol Injection Increased risk of metFORMIN-induced lactic acidosis Details Metformin Lanreotide Injection Somatuline An increased risk of hypoglycemia and impaired glucose regulation Details Metformin Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Metformin Levofloxacin Injection Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Metformin Abiraterone Acetate Abirtega An increased risk of severe hypoglycemia Details Metformin Abiraterone Acetate, Micronized Abirtega An increased risk of severe hypoglycemia Details Metformin Apalutamide Erleada Increased metFORMIN exposure and an increased risk of lactic acidosis Details Metformin Bictegravir Increased metFORMIN exposure and an increased risk of lactic acidosis Details Metformin Brinzolamide An increased risk of lactic acidosis and reduced serum bicarbonate Details Metformin Bupropion Aplenzin Reduced renal clearance of OCT2 substrates Details Metformin Cimetidine Tagamet Increased metFORMIN exposure and an increased risk of lactic acidosis Details Metformin Ciprofloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Metformin Dasabuvir Increased risk of lactic acidosis Details Metformin Diatrizoate Increased risk of acute decrease in renal function and occurrence of lactic acidosis Details Metformin Dichlorphenamide An increased risk of lactic acidosis and reduced serum bicarbonate Details Metformin Dorzolamide An increased risk of lactic acidosis and reduced serum bicarbonate Details Metformin Enoxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Metformin Ethiodized Oil Increased risk of acute decrease in renal function and occurrence of lactic acidosis Details Metformin Fedratinib Inrebic Increased metFORMIN exposure and an increased risk of metFORMIN-related adverse events Details Metformin Fexinidazole Increased metformin exposure Details Metformin Gatifloxacin Zymaxid Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details