Metformin

378 interactions 1 explained in plain English 428 cited references
Also sold as: Fortamet® Glucophage Glucophage® Glumetza Glumetza® Riomet Riomet® Trijardy® (as a combination product containing Empagliflozin, Linagliptin, Metformin)
About Metformin

Metformin is a biguanide medication used to help control blood sugar levels in type 2 diabetes. Read the full Metformin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ofloxacin Otic Ciprofloxacin Cimetidine Arimoclomol Insulin Glulisine (Rdna Origin) Injection Digoxin
99 Major 278 Moderate 1 Minor
All (378) Major (99) Moderate (278) Minor (1)

Moderate

Metformin Albuterol Oral Inhalation Accuneb® Explained An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Lisinopril Prinivil An increased risk of hypoglycemia Details Metformin Aspirin Acuprin® Increased risk of hypoglycemia Details Metformin Aspirin Rectal Aspirin Increased risk of hypoglycemia Details Metformin Atenolol Tenormin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Benazepril Lotensin An increased risk of hypoglycemia Details Metformin Amlodipine Amvaz® An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Beclomethasone Nasal Spray Beconase An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Beclomethasone Oral Inhalation Beclovent® An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Betaxolol Ophthalmic Betoptic® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Bisoprolol Zebeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Budesonide Entocort An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Budesonide Nasal Spray Rhinocort An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Budesonide Oral Inhalation Pulmicort An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Captopril Capoten® An increased risk of hypoglycemia Details Metformin Ciclesonide Nasal Spray Omnaris An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Ciclesonide Oral Inhalation Alvesco An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Clobetasol Byqlovi An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Clobetasol Topical Clobex® An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Clonidine Transdermal Patch Catapres An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Colesevelam Welchol Increased exposure to extended-release metformin Details Metformin Deflazacort Emflaza An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Desonide Desowen An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Desonide Topical Desonate® An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Desoximetasone Topicort An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Desoximetasone Topical Topicort An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Dexamethasone Injection Decadron An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Diflorasone Topical Apexicon An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Difluprednate Ophthalmic Durezol An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Droxidopa Northera An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Enalapril Epaned An increased risk of hypoglycemia Details Metformin Esmolol Brevibloc Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Estradiol Delestrogen An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Estradiol Topical Divigel An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Estradiol Transdermal Patch Alora® An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Estramustine Emcyt An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Felodipine Plendil® An increased risk of hyperglycemia and potential loss of glycemic control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.