Metformin

378 interactions 1 explained in plain English 428 cited references
Also sold as: Fortamet® Glucophage Glucophage® Glumetza Glumetza® Riomet Riomet® Trijardy® (as a combination product containing Empagliflozin, Linagliptin, Metformin)
About Metformin

Metformin is a biguanide medication used to help control blood sugar levels in type 2 diabetes. Read the full Metformin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ofloxacin Otic Ciprofloxacin Cimetidine Arimoclomol Insulin Glulisine (Rdna Origin) Injection Digoxin
99 Major 278 Moderate 1 Minor
All (378) Major (99) Moderate (278) Minor (1)

Moderate

Metformin Fludrocortisone Acetate Florinef® An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Flunisolide Nasal Spray Nasalide® An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Flunisolide Oral Inhalation AeroBid® Inhaler System An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Fluocinolone Capex An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Fluocinolone Topical Capex® Shampoo An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Fluocinonide Vanos An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Fluocinonide Topical Dermacin® An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Flurandrenolide Topical Cordran An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Fosinopril Monopril® An increased risk of hypoglycemia Details Metformin Furosemide Injection Disal An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Glimepiride Amaryl An increased risk of hypoglycemia Details Metformin Glipizide Glucotrol An increased risk of hypoglycemia Details Metformin Halcinonide Topical Halog An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Halobetasol Topical Duobrii (as a combination product containing Halobetasol, Tazarotene) An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Hydrocortisone Ala-Cort An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Hydrocortisone Injection A-Hydrocort® An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Isradipine DynaCirc® An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Labetalol Normodyne® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Levobunolol Ophthalmic AKBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Levonorgestrel After banger An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Levonorgestrel Intrauterine System Kyleena An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Levothyroxine Ermeza An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Linezolid Injection Zyvox An increased risk of hypoglycemia Details Metformin Liothyronine Cytomel An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Loteprednol Etabonate Alrex An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Loteprednol Ophthalmic Alrex An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Albuterol Sulfate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Alclometasone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Aldosterone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Amcinonide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Amiloride An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Amphetamine Dexedrine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Apraclonidine Hydrochloride An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Aranidipine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Arformoterol Tartrate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Armodafinil Nuvigil An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Atomoxetine Hydrochloride An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Beclomethasone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Bemetizide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Bendroflumethiazide An increased risk of hyperglycemia and potential loss of glycemic control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.