Metformin

378 interactions 1 explained in plain English 428 cited references
Also sold as: Fortamet® Glucophage Glucophage® Glumetza Glumetza® Riomet Riomet® Trijardy® (as a combination product containing Empagliflozin, Linagliptin, Metformin)
About Metformin

Metformin is a biguanide medication used to help control blood sugar levels in type 2 diabetes. Read the full Metformin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ofloxacin Otic Ciprofloxacin Cimetidine Arimoclomol Insulin Glulisine (Rdna Origin) Injection Digoxin
99 Major 278 Moderate 1 Minor
All (378) Major (99) Moderate (278) Minor (1)

Moderate

Metformin Benzthiazide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Bepridil An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Betamethasone Betavet An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Bitter Melon Increased risk of hypoglycemia Details Metformin Brimonidine Tartrate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Bumetanide Bumex An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Canrenoate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Canrenone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Carteolol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Carvedilol Coreg Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Celiprolol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Chlorothiazide Diuril An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Chlorotrianisene An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Chlorpromazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Chlorpropamide Diabinese® An increased risk of hypoglycemia Details Metformin Chlorthalidone Hemiclor An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Ciclesonide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Cilnidipine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Clevidipine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Clobetasone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Clocortolone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Clonidine Duraclon An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Clopamide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Conjugated / Estrogens Premarin An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Conjugated Estrogens Synthetic A An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Conjugated Estrogens Synthetic B An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Cortisone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Cyclopenthiazide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Cyclothiazide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Desogestrel An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Dexamethasone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Dexmethylphenidate Hydrochloride An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Dextroamphetamine Dexedrine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Diazoxide Proglycem An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Dienestrol An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Dienogest An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Diethylstilbestrol An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Diflorasone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Diflucortolone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Difluprednate An increased risk of hyperglycemia and potential loss of glycemic control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.