Metformin

378 interactions 1 explained in plain English 428 cited references
Also sold as: Fortamet® Glucophage Glucophage® Glumetza Glumetza® Riomet Riomet® Trijardy® (as a combination product containing Empagliflozin, Linagliptin, Metformin)
About Metformin

Metformin is a biguanide medication used to help control blood sugar levels in type 2 diabetes. Read the full Metformin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ofloxacin Otic Ciprofloxacin Cimetidine Arimoclomol Insulin Glulisine (Rdna Origin) Injection Digoxin
99 Major 278 Moderate 1 Minor
All (378) Major (99) Moderate (278) Minor (1)

Moderate

Metformin Diltiazem Cardizem An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Dixyrazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Drospirenone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Enalaprilat An increased risk of hypoglycemia Details Metformin Ephedrine Hydrochloride An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Ephedrine Sulfate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Epinephrine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Eplerenone Inspra An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Esterified Estrogens Menest An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Estetrol An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Estriol An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Estropipate Ogen An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Ethacrynic Acid Edecrin An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Ethinyl Estradiol An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Ethynodiol An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Etozolin An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Eucalyptus Increased risk of hypoglycemia Details Metformin Fenugreek Increased risk of hypoglycemia Details Metformin Flucloronide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Fludrocortisone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Flumethasone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Flunisolide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Fluocortin An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Fluocortolone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Fluorometholone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Fluphenazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Flurandrenolide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Fluticasone Aller-Flo An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Fluticasone Propionate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Formoterol Fumarate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Fosphenytoin Cerebyx An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Furosemide Disal An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Gestodene An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Ginseng Increased risk of hypoglycemia Details Metformin Glecaprevir Altered glycemic control resulting in severe symptomatic hypoglycemia Details Metformin Glucomannan Increased risk of hypoglycemia Details Metformin Glyburide DiaBeta® An increased risk of hypoglycemia Details Metformin Goldenseal Decreased metformin exposure Details Metformin Guar Gum Decreased effectiveness of metformin Details Metformin Gymnema Sylvestre Increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.