Metformin

378 interactions 1 explained in plain English 428 cited references
Also sold as: Fortamet® Glucophage Glucophage® Glumetza Glumetza® Riomet Riomet® Trijardy® (as a combination product containing Empagliflozin, Linagliptin, Metformin)
About Metformin

Metformin is a biguanide medication used to help control blood sugar levels in type 2 diabetes. Read the full Metformin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ofloxacin Otic Ciprofloxacin Cimetidine Arimoclomol Insulin Glulisine (Rdna Origin) Injection Digoxin
99 Major 278 Moderate 1 Minor
All (378) Major (99) Moderate (278) Minor (1)

Moderate

Metformin Halcinonide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Halobetasol An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Hydrastis Decreased metformin exposure Details Metformin Hydrochlorothiazide Inzirqo An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Hydroflumethiazide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Indapamide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Isocarboxazid Marplan An increased risk of hypoglycemia Details Metformin Isoniazid An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Isoproterenol Hydrochloride An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Lercanidipine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Levalbuterol Hydrochloride An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Levalbuterol Tartrate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Levobunolol Betagan Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Licorice Reduced antidiabetic agent effectiveness Details Metformin Linezolid Zyvox An increased risk of hypoglycemia Details Metformin Lisdexamfetamine Dimesylate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Loteprednol An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Manidipine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Medrysone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Mestranol An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Methamphetamine Hydrochloride An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Methdilazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Methotrimeprazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Methyclothiazide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Methylene Blue Provayblue An increased risk of hypoglycemia Details Metformin Methylphenidate Adhansia XR® An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Methylprednisolone Depo-Medrol An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Metipranolol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Metolazone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Metopimazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Metoprolol Kapspargo Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Midodrine Hydrochloride An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Modafinil Provigil An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Moexipril Univasc® An increased risk of hypoglycemia Details Metformin Mometasone Asmanex An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Nadolol Corgard Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Nateglinide Starlix® An increased risk of hypoglycemia Details Metformin Nebivolol Bystolic Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Niacin Endur-Acin An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Nicardipine Cardene An increased risk of hyperglycemia and potential loss of glycemic control Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.