Metformin

378 interactions 1 explained in plain English 428 cited references

Also sold as: Fortamet® Glucophage Glucophage® Glumetza Glumetza® Riomet Riomet® Trijardy® (as a combination product containing Empagliflozin, Linagliptin, Metformin)

About Metformin

Metformin is a biguanide medication used to help control blood sugar levels in type 2 diabetes. Read the full Metformin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ofloxacin Otic Ciprofloxacin Cimetidine Arimoclomol Insulin Glulisine (Rdna Origin) Injection Digoxin

99 Major 278 Moderate 1 Minor

All (378) Major (99) Moderate (278) Minor (1)

Moderate

Metformin Psyllium Alramucil® Increased risk of hypoglycemia Details Metformin Quinapril Accupril An increased risk of hypoglycemia Details Metformin Quinestrol An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Quinethazone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Ramipril Altace An increased risk of hypoglycemia Details Metformin Rasagiline Azilect An increased risk of hypoglycemia Details Metformin Repaglinide Prandin® An increased risk of hypoglycemia Details Metformin Rifampin Rifadin Increased metformin plasma concentrations; enhanced glucose lowering effects of metformin Details Metformin Rimexolone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Safinamide Xadago An increased risk of hypoglycemia Details Metformin Salmeterol Xinafoate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Selegiline Anipryl An increased risk of hypoglycemia Details Metformin Sotalol Betapace Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Spironolactone Aldactone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Terbutaline Sulfate An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Tetrahydrozoline Hydrochloride An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Thiethylperazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Thioproperazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Thioridazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Tibolone An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Timolol Betimol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Metformin Tolazamide Tolinase® An increased risk of hypoglycemia Details Metformin Tolbutamide Orinase® An increased risk of hypoglycemia Details Metformin Torsemide Soaanz An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Trandolapril Mavik® An increased risk of hypoglycemia Details Metformin Tranylcypromine Parnate An increased risk of hypoglycemia Details Metformin Triamcinolone Aller-Cort An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Triamterene Dyrenium An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Trichlormethiazide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Trifluoperazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Triflupromazine An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Ulipristal Ella An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Verapamil Calan Reduced glucose-lowering effect of metFORMIN, an increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Xipamide An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Methylphenidate Transdermal Patch Daytrana An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Mometasone Nasal Spray Nasonex An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Mometasone Oral Inhalation Asmanex An increased risk of hyperglycemia and potential loss of glycemic control Details Metformin Mometasone Topical Elocon® An increased risk of hyperglycemia and potential loss of glycemic control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.