Methacholine

26 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isoetharine Oral Inhalation Albuterol Oral Inhalation Trospium / Xanomeline Olodaterol Oral Inhalation Glycopyrronium Topical Cyclopentolate Ophthalmic
15 Major 11 Moderate
All (26) Major (15) Moderate (11)

Major

Methacholine Amitriptyline Elavil Explained Inhibition of the airway response to methacholine Details Methacholine Albuterol Oral Inhalation Accuneb® Explained Inhibition of the airway response to methacholine Details Methacholine Trospium / Xanomeline Cobenfy Explained Inhibition of the airway response to methacholine Details Methacholine Aclidinium Oral Inhalation Tudorza Inhibition of the airway response to methacholine Details Methacholine Atropine Ophthalmic Atropine Care 1% Inhibition of the airway response to methacholine Details Methacholine Cyclopentolate Ophthalmic Akpentolate® Inhibition of the airway response to methacholine Details Methacholine Diphenhydramine Injection Banophen Inhibition of the airway response to methacholine Details Methacholine Diphenhydramine Topical Afterbite with Antihistamine Inhibition of the airway response to methacholine Details Methacholine Glycopyrronium Topical Cuvposa® Inhibition of the airway response to methacholine Details Methacholine Indacaterol Oral Inhalation Arcapta® Inhibition of the airway response to methacholine Details Methacholine Ipratropium Nasal Spray Atrovent Nasal Spray® Inhibition of the airway response to methacholine Details Methacholine Ipratropium Oral Inhalation Atrovent® HFA Inhibition of the airway response to methacholine Details Methacholine Isoetharine Oral Inhalation Beta-2® Inhibition of the airway response to methacholine Details Methacholine Metaproterenol Alupent® Inhibition of the airway response to methacholine Details Methacholine Olodaterol Oral Inhalation Striverdi Inhibition of the airway response to methacholine Details

Moderate

Methacholine Atenolol Tenormin Explained Impaired reversal of methacholine-caused bronchoconstriction Details Methacholine Acebutolol Sectral® Impaired reversal of methacholine-caused bronchoconstriction Details Methacholine Betaxolol Betoptic S Impaired reversal of methacholine-caused bronchoconstriction Details Methacholine Betaxolol Ophthalmic Betoptic® Impaired reversal of methacholine-caused bronchoconstriction Details Methacholine Bisoprolol Zebeta® Impaired reversal of methacholine-caused bronchoconstriction Details Methacholine Esmolol Brevibloc Impaired reversal of methacholine-caused bronchoconstriction Details Methacholine Labetalol Normodyne® Impaired reversal of methacholine-caused bronchoconstriction Details Methacholine Levobunolol Ophthalmic AKBeta® Impaired reversal of methacholine-caused bronchoconstriction Details Methacholine Nadolol Corgard Impaired reversal of methacholine-caused bronchoconstriction Details Methacholine Nebivolol Bystolic Impaired reversal of methacholine-caused bronchoconstriction Details Methacholine Penbutolol Levatol® Impaired reversal of methacholine-caused bronchoconstriction Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.