Methotrexate Injection

354 interactions 996 cited references
Also sold as: Abitrexate® Folex® Jylamvo Mexate® Otrexup Otrexup® Rasuvo Rasuvo® Reditrex Reditrex® Trexall Xatmep
About Methotrexate Injection

Methotrexate injection is used alone or in combination with other medications: to treat certain types of acute lymphocytic leukemia (ALL) in adults and children; to treat or prevent meningeal leukemia (cancer in the covering of the spinal cord and brain) in adults and children; to treat certain types of non-Hodgkin's l… Read the full Methotrexate Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Methotrexate Injection Escitalopram Lexapro Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Esomeprazole Nexium Increased and prolonged plasma concentration of methotrexate and its metabolite Details Methotrexate Injection Ethambutol Myambutol Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Etodolac Lodine Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Etofenamate Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Etravirine Intelence Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Febuxostat Uloric Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Felbamate Felbatol Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Felbinac Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Fenbufen Methotrexate toxicity (leukopenia, thrombocytopenia, anemia, nephrotoxicity, mucosal ulcerations) Details Methotrexate Injection Fenoprofen Fenopron Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Fepradinol Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Feprazone Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Flecainide Tambocor® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Floctafenine Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Flucloxacillin Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Fluconazole Diflucan Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Flufenamic Acid Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Fluorouracil Adrucil Increased 5-fluorouracil toxicity Details Methotrexate Injection Flurbiprofen Ansaid Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Flutamide Eulexin Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Folic Acid Folacin Reduced folic acid exposure, reduced methotrexate exposure and reduced efficacy of methotrexate Details Methotrexate Injection Foscarnet Foscavir Nephrotoxicity Details Methotrexate Injection Fosfomycin Contepo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Fosphenytoin Cerebyx Reduced phenytoin or fosphenytoin (prodrug of phenytoin) exposure, reduced efficacy of phenytoin/fosphenytoin, an increased methot... Details Methotrexate Injection Fulvestrant Faslodex Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Furosemide Disal Increased methotrexate exposure, an increased risk of methotrexate-related toxicity, altered (increased/reduced) furosemide exposu... Details Methotrexate Injection Ganciclovir Cytovene® Oral Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Gatifloxacin Zymaxid Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Gemcitabine Avgemsi Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Gemtuzumab Ozogamicin Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Gliclazide Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Glimepiride Amaryl Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Glipizide Glucotrol Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Gliquidone Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Glyburide DiaBeta® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Golimumab Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Griseofulvin Fulvicin P/G Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Hydrochlorothiazide Inzirqo Increased methotrexate exposure and enhanced myelosuppression Details Methotrexate Injection Hydroxychloroquine Plaquenil Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.