Methotrexate Injection
354 interactions 996 cited referencesMethotrexate injection is used alone or in combination with other medications: to treat certain types of acute lymphocytic leukemia (ALL) in adults and children; to treat or prevent meningeal leukemia (cancer in the covering of the spinal cord and brain) in adults and children; to treat certain types of non-Hodgkin's l… Read the full Methotrexate Injection drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Methotrexate Injection Hydroxyurea Droxia Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Ibuprofen Addaprin Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Imatinib Gleevec Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Indapamide Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Indomethacin Indocin Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Infliximab Avsola Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Methotrexate Injection Interferon Beta-1A Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Interferon Beta-1B Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Isoniazid Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Itraconazole Sporanox Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Ixabepilone Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Ketoconazole Extina Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Ketoprofen Actron® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Ketorolac Acular Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Labetalol Normodyne® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Lamotrigine Lamictal Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Lansoprazole Prevacid An increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite... Details Methotrexate Injection Lapatinib Tykerb Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Leflunomide Arava Increased exposure of methotrexate and increased risk of hepatotoxicity and bone marrow toxicity Details Methotrexate Injection Leniolisib Joenja Increased methotrexate exposure Details Methotrexate Injection Levetiracetam Elepsia Increased risk of methotrexate exposure and toxicity Details Methotrexate Injection Levofloxacin Levaquin Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Linezolid Zyvox Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Lornoxicam Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Loxoprofen Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Lumiracoxib Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Lymecycline Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Mafenide Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Meclocycline Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Meclofenamate Meclodium® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Mefenamic Acid Ponstel® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Mefloquine Lariam® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Meloxicam Alloxate Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Memantine Namenda Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Mercaptopurine Purinethol® Mercaptopurine toxicity, increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, redu... Details Methotrexate Injection Mesalamine Apriso Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Methacycline Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Methazolamide Neptazane® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Methicillin Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... 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