Methotrexate Injection

354 interactions 996 cited references
Also sold as: Abitrexate® Folex® Jylamvo Mexate® Otrexup Otrexup® Rasuvo Rasuvo® Reditrex Reditrex® Trexall Xatmep
About Methotrexate Injection

Methotrexate injection is used alone or in combination with other medications: to treat certain types of acute lymphocytic leukemia (ALL) in adults and children; to treat or prevent meningeal leukemia (cancer in the covering of the spinal cord and brain) in adults and children; to treat certain types of non-Hodgkin's l… Read the full Methotrexate Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Methotrexate Injection Salicylic Acid Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Salsalate Disalcid Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Sapropterin Javygtor Decreased tetrahydrobiopterin (BH4) levels and increased phenylalanine levels Details Methotrexate Injection Sarecycline Seysara Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Secnidazole Solosec Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Sepiapterin Reduced sepiapterin metabolism to tetrahydrobiopterin Details Methotrexate Injection Silver Sulfadiazine Silvadene Increased methotrexate exposure, decreased metabolite formation and increased risk of adverse events and decreased efficacy Details Methotrexate Injection Simeprevir Olysio® Increased exposure of OATP1B1/3 substrate Details Methotrexate Injection Sirolimus Felycin Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Sodium Salicylate Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Sorafenib Nexavar Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Sulfacetamide Increased methotrexate exposure, decreased metabolite formation and increased risk of adverse events and decreased efficacy Details Methotrexate Injection Sulfacytine Increased methotrexate exposure, decreased metabolite formation and increased risk of adverse events and decreased efficacy Details Methotrexate Injection Sulfadiazine Microsulfon® Increased methotrexate exposure, decreased metabolite formation and increased risk of adverse events and decreased efficacy Details Methotrexate Injection Sulfamethizole An increased risk of methotrexate toxicity (myelotoxicity, pancytopenia, megaloblastic anemia) Details Methotrexate Injection Sulfamethoxazole Sustain An increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, r... Details Methotrexate Injection Sulfapyridine An increased risk of methotrexate toxicity (myelotoxicity, pancytopenia, megaloblastic anemia) Details Methotrexate Injection Sulfasalazine Azulfidine An increased risk of hepatotoxicity, increased methotrexate exposure, an increased risk of methotrexate-related severe adverse rea... Details Methotrexate Injection Sulfisoxazole An increased risk of methotrexate toxicity (myelotoxicity, pancytopenia, megaloblastic anemia) Details Methotrexate Injection Sulindac Clinoril® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Sultamicillin Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Sunitinib Sutent Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Tafamidis Vyndamax Increased BCRP substrate exposure and an increased risk of the substrate-related toxicities Details Methotrexate Injection Tamoxifen Nolvadex® An increased risk of thromboembolism, increased methotrexate exposure, an increased risk of methotrexate-related severe adverse re... Details Methotrexate Injection Tedizolid Phosphate Sivextro Increased BCRP substrates exposure and an increased risk of BCRP substrates-related adverse reactions Details Methotrexate Injection Tegafur Increased 5-fluorouracil toxicity Details Methotrexate Injection Temocillin Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Tenoxicam Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Terbinafine Lamisil Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Teriflunomide Aubagio Increased exposure of methotrexate and increased risk of hepatotoxicity and bone marrow toxicity Details Methotrexate Injection Testosterone Androderm Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Tetracycline Achromycin V® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Tiaprofenic Acid Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Ticarcillin Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Tigecycline Tygacil Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Tipranavir Aptivus Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Tizanidine Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Tolazamide Tolinase® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Tolbutamide Orinase® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Tolcapone Tasmar Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

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