Methotrexate Injection

354 interactions 996 cited references
Also sold as: Abitrexate® Folex® Jylamvo Mexate® Otrexup Otrexup® Rasuvo Rasuvo® Reditrex Reditrex® Trexall Xatmep
About Methotrexate Injection

Methotrexate injection is used alone or in combination with other medications: to treat certain types of acute lymphocytic leukemia (ALL) in adults and children; to treat or prevent meningeal leukemia (cancer in the covering of the spinal cord and brain) in adults and children; to treat certain types of non-Hodgkin's l… Read the full Methotrexate Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dengue Tetravalent Vaccine, Live Measles Virus Vaccine, Live Mumps Virus Vaccine, Live Varicella Virus Vaccine, Live Typhoid Vaccine Yellow Fever Vaccine
9 Contraindicated 332 Major 13 Moderate
All (354) Contraindicated (9) Major (332) Moderate (13)

Major

Methotrexate Injection Tolfenamic Acid Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Tolmetin Tolectin 600 Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Tolvaptan Jynarque Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Torsemide Soaanz Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Tramadol ConZip Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Triamterene Dyrenium Bone marrow suppression Details Methotrexate Injection Trimethoprim Primsol An increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, r... Details Methotrexate Injection Vadadustat Vafseo Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effect Details Methotrexate Injection Valdecoxib Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Valproic Acid Depakene® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Venlafaxine Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Vimseltinib Romvimza Increased risk of BCRP substrate exposure Details Methotrexate Injection Vincristine Marqibo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Voclosporin Lupkynis Increased OATP1B1 substrate exposure Details Methotrexate Injection Voriconazole Vfend Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Warfarin Coumadin Increased risk for elevated INR and subsequent bleeding; increased methotrexate exposure, an increased risk of methotrexate-relate... Details Methotrexate Injection Zafirlukast Accolate Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Zidovudine Retrovir Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Zolpidem Ambien Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Zonisamide Zonegran Increased methotrexate exposure, decreased metabolite formation and increased risk of adverse events and decreased efficacy Details Methotrexate Injection Zoster Vaccine, Live An increased risk of disseminated infections Details

Moderate

Methotrexate Injection Azathioprine Azasan An increased risk of hepatotoxicity Details Methotrexate Injection Cholestyramine Prevalite Decreased methotrexate effectiveness Details Methotrexate Injection Encorafenib Braftovi Increased methotrexate exposure and an increased risk of methotrexate-related toxicities Details Methotrexate Injection Etoricoxib Increased methotrexate plasma concentrations and toxicity Details Methotrexate Injection L-Methylfolate Decreased methotrexate and/or l-methylfolate efficacy Details Methotrexate Injection Oteseconazole Increased exposure to BCRP substrates Details Methotrexate Injection Procarbazine Renal dysfunction Details Methotrexate Injection Rolapitant Varubi Increased methotrexate exposure Details Methotrexate Injection Sars-Cov-2 (Covid-19) Vaccine, Adenovirus 26 Vector (Janssen) Decreased immune response to COVID-19 vaccine Details Methotrexate Injection Sars-Cov-2 (Covid-19) Vaccine, Mrna (Moderna) Decreased immune response to COVID-19 vaccine Details Methotrexate Injection Sars-Cov-2 (Covid-19) Vaccine, Mrna (Pfizer) Decreased immune response to COVID-19 vaccine Details Methotrexate Injection Theophylline Accurbron® Increased theophylline exposure Details Methotrexate Injection Zongertinib Hernexeos Increased BCRP substrates exposure and an increased risk of BCRP substrates-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.