Methyldopa

53 interactions 516 cited references
Also sold as: Aldomet®
About Methyldopa

Methyldopa is an antihypertensive medication used to treat high blood pressure. Read the full Methyldopa drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Moderate

Methyldopa Atenolol Tenormin Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Acebutolol Sectral® Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Betaxolol Betoptic S Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Betaxolol Ophthalmic Betoptic® Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Bisoprolol Zebeta® Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Esmolol Brevibloc Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Labetalol Normodyne® Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Levobunolol Ophthalmic AKBeta® Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Lithium Carbonate Lithobid An increased risk of toxic side effects Details Methyldopa Alprenolol Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Bevantolol Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Bucindolol Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Carteolol Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Carvedilol Coreg Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Celiprolol Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Dicumarol An increased risk of bleeding Details Methyldopa Dilevalol Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Ferric Ammonium Citrate Decreased methyldopa effectiveness Details Methyldopa Haloperidol CNS toxicity (dementia) or reversible parkinsonism Details Methyldopa Iron Decreased methyldopa effectiveness Details Methyldopa Levobunolol Betagan Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Lithium An increased risk of toxic side effects Details Methyldopa Ma Huang Reduced hypotensive effect of methyldopa Details Methyldopa Metipranolol Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Metoprolol Kapspargo Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Nadolol Corgard Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Nebivolol Bystolic Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Oxprenolol Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Penbutolol Levatol® Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Phenylpropanolamine Hypertension Details Methyldopa Pindolol Visken® Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Sotalol Betapace Exaggerated hypertensive response, tachycardia, or arrhythmias during physical stress or exposure to exogenous catecholamines Details Methyldopa Talinolol Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Tertatolol Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Timolol Betimol Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Methyldopa Tolcapone Tasmar Inhibition of methyldopa metabolism Details Methyldopa Yohimbine Reduced methyldopa effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.