Metoclopramide Nasal Spray

247 interactions 689 cited references
Also sold as: Gimoti Gimoti®
About Metoclopramide Nasal Spray

Metoclopramide nasal spray is used to relieve symptoms caused by slow stomach emptying in people who have diabetes. These symptoms include nausea, vomiting, heartburn, loss of appetite, and feeling of fullness that lasts long after meals. Metoclopramide is in a class of medications called prokinetic agents. It works by… Read the full Metoclopramide Nasal Spray drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Iloperidone Imipramine Levomilnacipran Loxapine Zuclopenthixol Mavorixafor
63 Contraindicated 174 Major 6 Moderate 4 Minor
All (247) Contraindicated (63) Major (174) Moderate (6) Minor (4)

Major

Metoclopramide Nasal Spray Quazepam Doral Increased risk of CNS depression Details Metoclopramide Nasal Spray Quinidine Cardioquin® Increased metoclopramide exposure and risk of increased adverse events Details Metoclopramide Nasal Spray Ramelteon Rozerem Increased risk of CNS depression Details Metoclopramide Nasal Spray Ranolazine Aspruzyo Increased CYP2D6 substrates exposure Details Metoclopramide Nasal Spray Rasagiline Azilect Increased risk of hypertensive crisis Details Metoclopramide Nasal Spray Remifentanil Increased risk of CNS depression Details Metoclopramide Nasal Spray Remoxipride Increased risk of CNS depression Details Metoclopramide Nasal Spray Rivastigmine Exelon Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Ropinirole Requip® Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Rotigotine Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Safinamide Xadago Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Secobarbital Increased risk of CNS depression Details Metoclopramide Nasal Spray Selegiline Anipryl Increased risk of hypertensive crisis Details Metoclopramide Nasal Spray Sirolimus Felycin An increased risk of sirolimus toxicity (anemia, leukopenia, thrombocytopenia, hypokalemia, diarrhea) Details Metoclopramide Nasal Spray Sodium Oxybate Lumryz An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Metoclopramide Nasal Spray Sufentanil Dsuvia Increased risk of CNS depression Details Metoclopramide Nasal Spray Suvorexant Belsomra Increased risk of CNS depression Details Metoclopramide Nasal Spray Tacrolimus Astagraf Increased tacrolimus exposure and an increased risk of tacrolimus toxicity Details Metoclopramide Nasal Spray Tapentadol Nucynta Increased risk of CNS depression Details Metoclopramide Nasal Spray Temazepam Restoril Increased risk of CNS depression Details Metoclopramide Nasal Spray Terbinafine Lamisil Increased metoclopramide exposure and risk of increased adverse events Details Metoclopramide Nasal Spray Thiethylperazine Increased risk of CNS depression Details Metoclopramide Nasal Spray Thiopental Increased risk of CNS depression Details Metoclopramide Nasal Spray Thiopropazate Increased risk of CNS depression Details Metoclopramide Nasal Spray Tizanidine Increased risk of CNS depression Details Metoclopramide Nasal Spray Tolonium Chloride Increased risk of CNS depression Details Metoclopramide Nasal Spray Topiramate Eprontia Increased risk of CNS depression Details Metoclopramide Nasal Spray Tramadol ConZip Increased risk of CNS depression Details Metoclopramide Nasal Spray Tranylcypromine Parnate Increased risk of serotonin syndrome or hypertensive crisis Details Metoclopramide Nasal Spray Triazolam Halcion Increased risk of CNS depression Details Metoclopramide Nasal Spray Trifluperidol Increased risk of CNS depression Details Metoclopramide Nasal Spray Trihexyphenidyl Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Nasal Spray Trimeprazine Increased risk of CNS depression Details Metoclopramide Nasal Spray Zaleplon Increased risk of CNS depression Details Metoclopramide Nasal Spray Zolpidem Ambien Increased risk of CNS depression Details Metoclopramide Nasal Spray Zopiclone Increased risk of CNS depression Details Metoclopramide Nasal Spray Zotepine Increased risk of CNS depression Details

Moderate

Metoclopramide Nasal Spray Atovaquone Mepron Reduction of atovaquone bioavailability Details Metoclopramide Nasal Spray Didanosine Videx® Increased didanosine plasma concentrations Details Metoclopramide Nasal Spray Kava Additive DOPamine antagonist effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.