Metronidazole Vaginal

242 interactions 832 cited references
Also sold as: MetroGel® Vaginal Nuvessa Nuvessa® Vandazole Vandazole®
About Metronidazole Vaginal

Metronidazole is used to treat vaginal infections such as bacterial vaginosis (an infection caused from too much of certain bacteria in the vagina). Metronidazole is in a class of medications called nitroimidazole antimicrobials. It works by stopping the growth of bacteria. Read the full Metronidazole Vaginal drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Moderate

Metronidazole Vaginal Anisindione An increased risk of bleeding Details Metronidazole Vaginal Carbamazepine Carbatrol Increased carbamazepine serum concentrations and potential carbamazepine toxicity Details Metronidazole Vaginal Cholestyramine Prevalite Decreased metronidazole effectiveness Details Metronidazole Vaginal Cyclosporine Atopica An increased risk of cycloSPORINE toxicity (nephrotoxicity, cholestasis, paresthesias) Details Metronidazole Vaginal Dicumarol An increased risk of bleeding Details Metronidazole Vaginal Dihydroergotamine Brekiya Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Metronidazole Vaginal Ergoloid Mesylates Alkergot® Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Metronidazole Vaginal Ergonovine Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Metronidazole Vaginal Ergotamine Ergomar Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Metronidazole Vaginal Lixisenatide Delayed therapeutic effect Details Metronidazole Vaginal Methylergonovine Methergine Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Metronidazole Vaginal Milk Thistle Reduced metronidazole and active metabolite exposure Details Metronidazole Vaginal Phenindione An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.