Metronidazole Vaginal

242 interactions 832 cited references

Also sold as: MetroGel® Vaginal Nuvessa Nuvessa® Vandazole Vandazole®

About Metronidazole Vaginal

Metronidazole is used to treat vaginal infections such as bacterial vaginosis (an infection caused from too much of certain bacteria in the vagina). Metronidazole is in a class of medications called nitroimidazole antimicrobials. It works by stopping the growth of bacteria. Read the full Metronidazole Vaginal drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Pimozide Piperaquine Saquinavir Sparfloxacin Terfenadine Thioridazine

15 Contraindicated 214 Major 13 Moderate

All (242) Contraindicated (15) Major (214) Moderate (13)

Contraindicated

Metronidazole Vaginal Amprenavir An increased risk of propylene glycol toxicity (seizures, tachycardia, lactic acidosis, renal toxicity, hemolysis) Details Metronidazole Vaginal Bepridil An increased risk of QT interval prolongation Details Metronidazole Vaginal Cisapride Propulsid® Increased risk of QT interval prolongation Details Metronidazole Vaginal Disulfiram Antabuse An increased risk of psychotic reactions Details Metronidazole Vaginal Dronabinol Marinol Disulfiram-like reaction Details Metronidazole Vaginal Dronedarone Multaq Increased risk of QT interval prolongation Details Metronidazole Vaginal Levoketoconazole Recorlev An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Metronidazole Vaginal Mesoridazine An increased risk of QT interval prolongation Details Metronidazole Vaginal Pimozide An increased risk of QT interval prolongation Details Metronidazole Vaginal Piperaquine An increased risk of QT interval prolongation Details Metronidazole Vaginal Saquinavir An increased risk of QT interval prolongation Details Metronidazole Vaginal Sparfloxacin An increased risk of QT interval prolongation Details Metronidazole Vaginal Terfenadine An increased risk of QT interval prolongation Details Metronidazole Vaginal Thioridazine An increased risk of QT interval prolongation Details Metronidazole Vaginal Ziprasidone Geodon An increased risk of QT interval prolongation Details

Major

Metronidazole Vaginal Acenocoumarol An increased risk of bleeding Details Metronidazole Vaginal Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Metronidazole Vaginal Alfuzosin UroXatral An increased risk of QT interval prolongation Details Metronidazole Vaginal Amiodarone Nexterone An increased risk of QT interval prolongation and torsade de pointes Details Metronidazole Vaginal Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Metronidazole Vaginal Amitriptyline Elavil An increased risk of QT interval prolongation Details Metronidazole Vaginal Anagrelide Agrylin An increased risk of QT interval prolongation Details Metronidazole Vaginal Apomorphine Apokyn An increased risk of QT interval prolongation Details Metronidazole Vaginal Aripiprazole Abilify An increased risk of QT interval prolongation Details Metronidazole Vaginal Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Metronidazole Vaginal Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Metronidazole Vaginal Artemether An increased risk of QT interval prolongation Details Metronidazole Vaginal Asenapine Saphris An increased risk of QT interval prolongation Details Metronidazole Vaginal Astemizole An increased risk of QT interval prolongation Details Metronidazole Vaginal Atazanavir Reyataz An increased risk of QT interval prolongation Details Metronidazole Vaginal Azithromycin AzaSite An increased risk of QT interval prolongation Details Metronidazole Vaginal Bedaquiline Sirturo An increased risk of QT interval prolongation Details Metronidazole Vaginal Buprenorphine Belbuca An increased risk of QT interval prolongation Details Metronidazole Vaginal Bupropion Aplenzin Increased risk of seizures Details Metronidazole Vaginal Busulfan Busulfex Increased busulfan exposure and an increased risk of busulfan toxicity Details Metronidazole Vaginal Capecitabine Xeloda Increased exposure of 5-fluorouracil Details Metronidazole Vaginal Ceritinib Zykadia An increased risk of QT interval prolongation Details Metronidazole Vaginal Chloroquine Aralen® An increased risk of QT interval prolongation Details Metronidazole Vaginal Chlorpromazine An increased risk of QT interval prolongation Details Metronidazole Vaginal Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.