Mexiletine

Name: Mexiletine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

82 interactions 465 cited references

Also sold as: Mexitil®

About Mexiletine

Mexiletine is used to treat certain types of ventricular arrhythmias (abnormal heart rhythms). Mexiletine is in a class of medications called antiarrhythmics. It works by blocking certain electrical signals in the heart to stabilize the heart rhythm. Read the full Mexiletine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Vernakalant Levomethadyl Fezolinetant Mavorixafor Viloxazine Warfarin

5 Contraindicated 64 Major 13 Moderate

All (82) Contraindicated (5) Major (64) Moderate (13)

Moderate

Mexiletine Rifapentine Priftin Decreased antiarrhythmic effectiveness Details Mexiletine Ritonavir Norvir Increased mexiletine serum concentrations and potential toxicity (nausea, dizziness, cardiac arrhythmias) Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.