Mexiletine

Contraindicated

Mexiletine Fezolinetant Increased fezolinetant exposure Details Mexiletine Levomethadyl An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Mexiletine Mavorixafor Xolremdi Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Mexiletine Vernakalant Increased risk of atrial flutter and other cardiovascular events Details Mexiletine Viloxazine Qelbree Increased exposure of CYP2D6 substrates that are CYP1A2 sensitive or NTI substrates and an increased risk of CYP2D6 substrates tha... Details

Major

Mexiletine Abametapir Increased exposure of CYP1A2 substrates Details Mexiletine Sertraline Increased CYP2D6 substrate exposure Details Mexiletine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Mexiletine Anagrelide Agrylin Increased anagrelide exposure Details Mexiletine Bendamustine Injection Belrapzo Increased bendamustine exposure and an increased risk of bendamustine-related adverse effects Details Mexiletine Capmatinib Tabrecta Increased CYP1A2 substrate exposure and an increased risk of adverse reactions Details Mexiletine Dacomitinib Vizimpro Increased exposure of the CYP2D6 substrate Details Mexiletine Disopyramide Norpace Disopyramide toxicity (cardiac arrhythmias, hypotension, syncope) and an increased risk of cardiotoxicity (QT prolongation, torsad... Details Mexiletine Enasidenib Idhifa Increased CYP1A2 substrate exposure and an increased risk of CYP1A2 substrate-related adverse effects Details Mexiletine Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Mexiletine Abiraterone Acetate Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Mexiletine Abiraterone Acetate, Micronized Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Mexiletine Adagrasib Krazati Increased exposure to CYP2D6 substrates and an increased risk of CYP2D6 substrates-relate adverse effects Details Mexiletine Amiodarone Nexterone Increased antiarrhythmic levels Details Mexiletine Atazanavir Reyataz Increased antiarrhythmics exposure Details Mexiletine Bendamustine Increased bendamustine exposure and an increased risk of bendamustine-related adverse effects Details Mexiletine Berotralstat Orladeyo Increased CYP2D6 substrate exposure Details Mexiletine Bupropion Aplenzin Increased exposure of CYP2D6 substrates Details Mexiletine Cannabidiol Epidiolex Increased CYP1A2 substrate with NTI exposure and an increased risk of CYP1A2 substrate-related adverse reactions Details Mexiletine Carbamazepine Carbatrol Reduced CYP1A2 substrate exposure and reduced efficacy of CYP1A2 substrate Details Mexiletine Celecoxib Celebrex Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Mexiletine Ciprofloxacin Increased CYP1A2 substrate exposure and an increased risk of CYP1A2 substrate-related adverse reactions Details Mexiletine Clomipramine Anafranil Increased clomiPRAMINE exposure Details Mexiletine Clozapine Clozaril Increased clozapine exposure Details Mexiletine Dasabuvir Increased plasma concentration of antiarrhythmic agent Details Mexiletine Desvenlafaxine Pristiq Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Mexiletine Diazoxide Proglycem Increased CYP1A2 substrate exposure and an increased risk of CYP1A2 substrate-related adverse reactions Details Mexiletine Dihydroartemisinin Increased exposure of CYP1A2 substrate Details Mexiletine Duloxetine Increased CYP2D6 substrate exposure Details Mexiletine Epinephrine An increased risk of cardiac arrhythmias Details Mexiletine Escitalopram Lexapro Increased CYP2D6 substrate exposure Details Mexiletine Etravirine Intelence Decreased mexiletine plasma concentrations Details Mexiletine Fedratinib Inrebic Increased CYP2D6 substrate exposure Details Mexiletine Fluoxetine RECONCILE Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Mexiletine Fosphenytoin Cerebyx Reduced mexiletine exposure Details