Drug & supplement interaction

Aloe + Mexiletine

Mexiletine brand name: Mexitil.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Aloe has a minor interaction with Mexiletine. Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Aloe and Mexiletine

Here is the interaction we found between these two, with the evidence behind it.

Minor

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES

Why this applies to Mexiletine

Mexiletine falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Aloe interacts with.

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for mexiletine: your liver clears it using an enzyme called CYP1A2. Lab studies hint that oral aloe might speed that enzyme up (called induction). If that happened in real life, your body could clear mexiletine a little faster, which might lower its blood levels and make it work less well at keeping your heart rhythm steady.

I want to be honest about the evidence though, this is only seen in test-tube and animal research, not in actual patients. The interaction is rated minor. Still, because mexiletine controls a serious heart rhythm problem, even small shifts deserve a quick chat. Before starting oral aloe, please check with your pharmacist or cardiologist. Aloe gel used on your skin isn't a concern here.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Aloe Also Interacts With Other Medications

Aloe has 1 major, 304 moderate, 155 minor known drug interactions in our database — the Mexiletine one above is one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 304 Minor 155 No known interaction 2,370 (incl. Mexiletine)
Taking anything else?

Check Another of Your Medications Against Aloe

Covers the 2,830 medications we’ve checked against Aloe. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Mexiletine

This page covers Aloe only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mexiletine page lists 152 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), 1,3-dmaa (moderate), Acacia Rigidula (moderate), Active Hexose Correlated Compound (ahcc) (moderate) and Adrafinil (moderate).

By severity: 1 major · 107 moderate · 44 minor.

From our pharmacist’s overview on the Mexiletine page

“Mexiletine (Mexitil) steadies the heart's rhythm, and its benefit depends on holding a fairly precise blood level, so the 152 supplements on this list deserve real attention rather than a shrug. Only one entry, activated charcoal, is rated major, because it can soak up the drug in the gut and cut how much actually reaches your bloodstr…”

Reviewed by 2 · Jul 18, 2026

Open the Mexiletine interaction page

One more smart check

Taking Aloe as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,978 real supplement products containing Aloe, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Aloe. Your product may carry other ingredients that interact with Mexiletine too, on top of Aloe — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Aloe and Mexiletine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Aloe
Top 10%

#86 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mexiletine
Top half

#1,403 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Aloe

What is Aloe?

Aloe
  • Minor burns and skin irritation
  • Wound healing
  • Constipation
  • Skin hydration and moisturizing
  • Digestive complaints
  • Hair and scalp care

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and is not considered safe for regular use. Talk to your pharmacist or doctor before taking aloe by mouth, and avoid oral aloe during pregnancy.

Read the full Aloe monograph & all interactions
Medication

About Mexiletine

What Is Mexiletine Used For?

Brand name: Mexitil

Mexiletine Hydrochloride capsules are indicated for the treatment of documented, life-threatening ventricular arrhythmias — for example, sustained ventricular tachycardia (a dangerously fast heart rhythm originating in the lower chambers). Because mexiletine itself can trigger arrhythmias, it is not recommended for minor or symptom-free irregular heartbeats.

Treatment is started in a hospital setting so heart rhythm can be monitored closely. Antiarrhythmic drugs, including mexiletine, have not been shown to improve overall survival in patients with ventricular arrhythmias.

See full Mexiletine drug information
Keep checking

Other Drugs & Aloe

Browse every other medication we’ve checked against Aloe — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
304Moderate
155Minor
2,369No known interaction
1 Major 304 Moderate 155 Minor 2,369 No interaction
Major

1 interaction

Moderate

304 interactions

Showing 60 of 304 moderate interactions — see all 304 on the Aloe page.

Minor

155 interactions

Showing 60 of 155 minor interactions — see all 155 on the Aloe page.

No interaction 2,369 drugs checked — show the list

We also checked Aloe against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,369 medications checked with no known interaction — see the full Aloe list.

See the full Aloe interactions page
See every supplement checked against Mexiletine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Aloe monograph › Uses, safety, and every drug interaction in one place Mexiletine supplement interactions › Every supplement checked against Mexiletine, ranked by severity Mexiletine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Aloe and Mexiletine Together: Common Questions

Can you take Aloe with Mexiletine?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Aloe and Mexiletine interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Mexiletine and Aloe?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.