Drug & supplement interaction

Broccoli Sprout + Mexiletine

Mexiletine brand name: Mexitil.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Broccoli Sprout has a minor interaction with Mexiletine. Theoretically, broccoli sprout might reduce levels and effects of drugs metabolized by CYP1A2.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Broccoli Sprout and Mexiletine

Here is the interaction we found between these two, with the evidence behind it.

Minor

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES

Why this applies to Mexiletine

Mexiletine falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Broccoli Sprout interacts with.

Theoretically, broccoli sprout might reduce levels and effects of drugs metabolized by CYP1A2.
Animal research shows that broccoli sprout extract can increase CYP1A2 gene expression. Also, pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to glucosinolate constituents, which are also found in broccoli sprout.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: your body clears mexiletine mainly through a liver enzyme called CYP1A2. Broccoli sprouts contain compounds that may gently speed that enzyme up. If that enzyme works faster, it could clear mexiletine a little quicker, which in theory might lower its blood levels and make it slightly less effective at keeping your heart rhythm steady. Mexiletine is an active drug (not a prodrug), so faster clearance means weaker effect, not stronger.

Now, don't panic. This is rated minor and is only theoretical, based on how the enzyme behaves. Everyday culinary amounts of broccoli sprouts on a salad are very unlikely to matter. The bigger question mark is concentrated sprout supplements taken daily. Since mexiletine controls a serious heart rhythm, just run any supplement plan past your doctor or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  2. Yoshida K, Ushida Y, Ishijima T, et al. Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury. World J Gastroenterol. 2015;21(35):10091-103. PubMed
  3. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Broccoli Sprout Also Interacts With Other Medications

Broccoli Sprout has 186 minor known drug interactions in our database — the Mexiletine one above is one of them. If you take anything else, check it against the full list below.

Minor 186 No known interaction 2,644 (incl. Mexiletine)
Taking anything else?

Check Another of Your Medications Against Broccoli Sprout

Covers the 2,830 medications we’ve checked against Broccoli Sprout. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Mexiletine

This page covers Broccoli Sprout only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mexiletine page lists 152 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), 1,3-dmaa (moderate), Acacia Rigidula (moderate), Active Hexose Correlated Compound (ahcc) (moderate) and Adrafinil (moderate).

By severity: 1 major · 107 moderate · 44 minor.

From our pharmacist’s overview on the Mexiletine page

“Mexiletine (Mexitil) steadies the heart's rhythm, and its benefit depends on holding a fairly precise blood level, so the 152 supplements on this list deserve real attention rather than a shrug. Only one entry, activated charcoal, is rated major, because it can soak up the drug in the gut and cut how much actually reaches your bloodstr…”

Reviewed by 2 · Jul 18, 2026

Open the Mexiletine interaction page

One more smart check

Taking Broccoli Sprout as Part of a Dietary Supplement Product? Check It for Interactions

We hold 184 real supplement products containing Broccoli Sprout, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Broccoli Sprout. Your product may carry other ingredients that interact with Mexiletine too, on top of Broccoli Sprout — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Broccoli Sprout and Mexiletine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Broccoli Sprout
Steady interest

#1,214 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mexiletine
Top half

#1,394 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Broccoli Sprout

What is Broccoli Sprout?

  • Antioxidant support
  • Detoxification support
  • General heart health
  • Anti-inflammatory support
  • Digestive and gut health

Broccoli sprouts are young broccoli seedlings rich in a compound called sulforaphane, which is being studied for antioxidant, anti-inflammatory, and detoxification effects. Early research is promising for some uses, but high-quality human evidence is still limited, so they should be viewed as a healthy food rather than a proven treatment. As food they are generally safe, but talk to your pharmacist or doctor before using concentrated supplements, especially during pregnancy or breastfeeding.

Read the full Broccoli Sprout monograph & all interactions
Medication

About Mexiletine

What Is Mexiletine Used For?

Brand name: Mexitil

Mexiletine Hydrochloride capsules are indicated for the treatment of documented, life-threatening ventricular arrhythmias — for example, sustained ventricular tachycardia (a dangerously fast heart rhythm originating in the lower chambers). Because mexiletine itself can trigger arrhythmias, it is not recommended for minor or symptom-free irregular heartbeats.

Treatment is started in a hospital setting so heart rhythm can be monitored closely. Antiarrhythmic drugs, including mexiletine, have not been shown to improve overall survival in patients with ventricular arrhythmias.

See full Mexiletine drug information
Keep checking

Other Drugs & Broccoli Sprout

Browse every other medication we’ve checked against Broccoli Sprout — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
186Minor
2,643No known interaction
186 Minor 2,643 No interaction
Minor

186 interactions

Showing 60 of 186 minor interactions — see all 186 on the Broccoli Sprout page.

No interaction 2,643 drugs checked — show the list

We also checked Broccoli Sprout against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,643 medications checked with no known interaction — see the full Broccoli Sprout list.

See the full Broccoli Sprout interactions page
See every supplement checked against Mexiletine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Broccoli Sprout monograph › Uses, safety, and every drug interaction in one place Mexiletine supplement interactions › Every supplement checked against Mexiletine, ranked by severity Mexiletine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Broccoli Sprout and Mexiletine Together: Common Questions

Can you take Broccoli Sprout with Mexiletine?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Broccoli Sprout and Mexiletine interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Mexiletine and Broccoli Sprout?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.