Drug & supplement interaction

Broccoli Sprout + Doxycycline

Doxycycline brand names: Vibra-Tabs, Vibramycin, Doryx, Monodox, Doxycin, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Broccoli Sprout and Doxycycline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Doxycycline states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Broccoli Sprout and Doxycycline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Doxycycline and Broccoli Sprout in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Broccoli Sprout safety at a glance

Broccoli Sprout overall Use caution Generally safe as a food, but concentrated supplements are less studied and quality varies.
Pregnancy Likely Safe When COOKED broccoli sprouts are consumed in amounts commonly found in foods. Broccoli sprout is considered safe for dietary consumption provided the sprouts ar... Read the full pregnancy detail
Breastfeeding Likely Safe When COOKED broccoli sprouts are consumed in amounts commonly found in foods. Broccoli sprout is considered safe for dietary consumption provided the sprouts ar... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Doxycycline and Broccoli Sprout? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Doxycycline

Interactions in our licensed database are recorded against drug classes, not just single drug names. Doxycycline is filed under 9 classifications — including tetracycline antibiotics, antibiotic drugs, p-glycoprotein substrates. Broccoli Sprout has documented interactions with 2 drug classes — the most serious being cytochrome p450 1a2 (cyp1a2) substrates (minor) and cytochrome p450 2a6 (cyp2a6) substrates (minor) — and none of Doxycycline’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Broccoli Sprout Does Interact With Other Medications

Broccoli Sprout has 187 minor known drug interactions in our database — Doxycycline isn’t one of them. If you take anything else, check it against the full list below.

Minor 187 No known interaction 2,643 (incl. Doxycycline)
Taking anything else?

Check Another of Your Medications Against Broccoli Sprout

Covers the 2,830 medications we’ve checked against Broccoli Sprout. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Broccoli Sprout and Doxycycline May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach pain / Diarrhea Additional detail

    Broccoli Sprout

    “Orally, loose stools, diarrhea, abdominal pain, and abdominal cramping have been reported following intake of broccoli seed and broccoli sprout extracts, particularly at high doses. Consuming raw broccoli sprouts that have been improperly grown may cause food-borne illness. Improperly grown broccoli sprouts may be contaminated with bacteria, including Listeria monocytogenes, Salmonella, or Escherichia coli O157:H7.”

    Broccoli Sprout · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 114753. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed
    2. 26423. Gorski L, Flaherty D, Duhe JM. Comparison of the stress response of Listeria monocytogenes strains with sprout colonization. J Food Prot 2008;71(8):1556-1562. PubMed
    3. 26424. Fahey JW, Ourisson PJ, Degnan FH. Pathogen detection, testing, and control in fresh broccoli sprouts. Nutr J 2006;5:13. PubMed
    4. 26425. Rajkowski KT, Boyd G, Thayer DW. Irradiation D-values for Escherichia coli O157:H7 and Salmonella sp. on inoculated broccoli seeds and effects of irradiation on broccoli sprout keeping quality and seed viability. J Food Prot 2003;66(5):760-766. PubMed

    Doxycycline

    Listed in the ADVERSE REACTIONS section of the FDA label for Doxycycline. Read the label on DailyMed ›

Effects for Doxycycline come from the ADVERSE REACTIONS section of its FDA label; effects for Broccoli Sprout come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Broccoli Sprout in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When COOKED broccoli sprouts are consumed in amounts commonly found in foods. Broccoli sprout is considered safe for dietary consumption provided the sprouts are grown in accordance with food safety recommendations developed by the US Food and Drug Administration (FDA) and are cooked prior to eating.

Pregnancy And Lactation Possibly Unsafe

When RAW broccoli sprouts are consumed in amounts commonly found in foods. There is evidence that uncooked broccoli sprouts may be contaminated with bacteria, including Listeria monocytogenes, Salmonella, or Escherichia coli O157:H7. Pregnant individuals are particularly susceptible to these food-borne illnesses, and becoming infected can increase the risk of miscarriage, stillbirth, premature birth, or neonatal infection. There is insufficient reliable information available about the safety of broccoli sprout extract during pregnancy or lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Doxycycline Products Have a Food Rule — Broccoli Sprout Should Not Break It

At least one FDA label for a product containing Doxycycline says to take it on an empty stomach. Most supplements — Broccoli Sprout included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Doxycycline on its own and move Broccoli Sprout to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Doxycycline products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Take one Doxycycline capsule (40 mg) once daily in the morning on an empty stomach, preferably at least one hour prior to or two hours after meals.

From the Dosage and Administration section of the FDA label we read for Doxycycline — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Broccoli Sprout or Doxycycline

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Broccoli Sprout or Doxycycline, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Doxycycline

This page covers Broccoli Sprout only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Doxycycline page lists 166 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Oleander (major) and Siberian Cocklebur (major).

By severity: 7 major · 139 moderate · 20 minor.

From our pharmacist’s overview on the Doxycycline page

“St. John's wort is the supplement I would flag first for anyone on doxycycline (Vibramycin, Doryx), because it can speed the antibiotic out of the body and leave an infection undertreated.”

Reviewed by 2 · Jul 18, 2026

Open the Doxycycline interaction page

One more smart check

Taking Broccoli Sprout as Part of a Dietary Supplement Product? Check It for Interactions

We hold 184 real supplement products containing Broccoli Sprout, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Broccoli Sprout. Even though Broccoli Sprout itself has no known interaction with Doxycycline, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Broccoli Sprout and Doxycycline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Broccoli Sprout
Steady interest

#1,216 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Doxycycline
Top 5%

#41 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Broccoli Sprout reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Broccoli Sprout and Doxycycline records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Broccoli Sprout

What is Broccoli Sprout?

  • Antioxidant support
  • Detoxification support
  • General heart health
  • Anti-inflammatory support
  • Digestive and gut health

Broccoli sprouts are young broccoli seedlings rich in a compound called sulforaphane, which is being studied for antioxidant, anti-inflammatory, and detoxification effects. Early research is promising for some uses, but high-quality human evidence is still limited, so they should be viewed as a healthy food rather than a proven treatment. As food they are generally safe, but talk to your pharmacist or doctor before using concentrated supplements, especially during pregnancy or breastfeeding.

Brassica oleracea var. italica · Brassicaceae · Young sprouts (seedlings) of the broccoli plant · Fresh sprouts, powders, capsules, tablets, and standardized extracts (often labeled as containing sulforaphane or glucoraphanin)

An interaction check asks whether these two react with each other — it does not ask whether Broccoli Sprout is a good idea for someone in your situation. Here is what our Broccoli Sprout record says about it on its own.

Broccoli Sprout: dosing

There is no official standardized dose for broccoli sprouts or their extracts. Studies have used different forms and amounts, often described by the amount of glucoraphanin or sulforaphane, which makes comparison difficult.If you are eating them as food, a serving as part of a balanced diet is reasonable. If you choose a supplement, follow the directions on the product label and choose a reputable brand.

From our Broccoli Sprout monograph — the full record covers uses, side effects and every documented interaction.

Read the full Broccoli Sprout monograph & all interactions
Medication

About Doxycycline

What Is Doxycycline Used For?

Brand names: Vibra-Tabs, Vibramycin, Doryx, Monodox, Doxycin, Doxy, Doxylin, Doxy-D, Periostat, Doxycycline Injection, Oracea, Xyrosa

Doxycycline belongs to the tetracycline family of antibiotics. It's prescribed for many types of bacterial infections, including respiratory tract infections, sexually transmitted infections (STIs), tick-borne illnesses like Rocky Mountain spotted fever, and eye infections. It's also used to help prevent malaria and, in some cases, as a helper treatment for severe acne.

In situations where penicillin-type antibiotics can't be used — due to allergy, for example — doxycycline can step in as an alternative. It should only be used for infections that are proven or strongly suspected to be caused by bacteria.

See full Doxycycline drug information
Keep checking

Other Drugs & Broccoli Sprout

Browse every other medication we’ve checked against Broccoli Sprout — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
187Minor
2,642No known interaction
187 Minor 2,642 No interaction
Minor

187 interactions

Showing 60 of 187 minor interactions — see all 187 on the Broccoli Sprout page.

No interaction 2,642 drugs checked — show the list

We also checked Broccoli Sprout against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,642 medications checked with no known interaction — see the full Broccoli Sprout list.

See the full Broccoli Sprout interactions page
See every supplement checked against Doxycycline, ranked by severity
Evidence & sources

Broccoli Sprout References

The 8 references that drive our Broccoli Sprout monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  2. Pezdirc KB, Hure AJ, Blumfield ML, Collins CE. Listeria monocytogenes and diet during pregnancy; balancing nutrient intake adequacy v. adverse pregnancy outcomes. Public Health Nutr 2012;15(12):2202-9.
  3. Gorski L, Flaherty D, Duhe JM. Comparison of the stress response of Listeria monocytogenes strains with sprout colonization. J Food Prot 2008;71(8):1556-1562. PubMed
  4. Fahey JW, Ourisson PJ, Degnan FH. Pathogen detection, testing, and control in fresh broccoli sprouts. Nutr J 2006;5:13. PubMed
  5. Rajkowski KT, Boyd G, Thayer DW. Irradiation D-values for Escherichia coli O157:H7 and Salmonella sp. on inoculated broccoli seeds and effects of irradiation on broccoli sprout keeping quality and seed viability. J Food Prot 2003;66(5):760-766. PubMed
  6. Yoshida K, Ushida Y, Ishijima T, et al. Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury. World J Gastroenterol. 2015;21(35):10091-103. PubMed
  7. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  8. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Broccoli Sprout and Doxycycline Together: Common Questions

Is it safe to take Broccoli Sprout with Doxycycline?
We do not list a known interaction between Broccoli Sprout and Doxycycline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Broccoli Sprout and Doxycycline have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Broccoli Sprout and Doxycycline at the same time of day?
At least one FDA label for a product containing Doxycycline says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Doxycycline on its own and move Broccoli Sprout to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Broccoli Sprout and Doxycycline combination checked?
Interactions in our licensed database are recorded against drug classes. Doxycycline is filed under 9 classifications, and Broccoli Sprout has documented interactions with 2 drug classes — none of Doxycycline's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Broccoli Sprout interact with any other medications?
Yes. Broccoli Sprout has 187 documented drug interactions in our database — Doxycycline is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Doxycycline interact with any supplements?
Yes. Doxycycline has documented interactions with 166 supplements in our database — Broccoli Sprout is not one of them. The Doxycycline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Broccoli Sprout monograph Uses, safety profile, and every drug interaction in one place Doxycycline drug information The full plain-English guide to this medication Doxycycline supplement interactions Every supplement checked against Doxycycline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Doxycycline and Broccoli Sprout?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.