Mibefradil

20 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Simvastatin Lurasidone Lovastatin Digoxin Atorvastatin
4 Contraindicated 15 Major 1 Minor
All (20) Contraindicated (4) Major (15) Minor (1)

Contraindicated

Mibefradil Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Mibefradil Simvastatin Flolipid Explained An increased risk of myopathy and/or rhabdomyolysis Details Mibefradil Lovastatin Altocor® An increased risk of myopathy and/or rhabdomyolysis Details Mibefradil Lurasidone Latuda Increased lurasidone exposure Details

Major

Mibefradil Relugolix Orgovyx Explained Increased relugolix exposure Details Mibefradil Atorvastatin Atorvaliq An increased risk of myopathy and/or rhabdomyolysis Details Mibefradil Anagrelide Agrylin Increased anagrelide exposure Details Mibefradil Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Mibefradil Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Mibefradil Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Mibefradil Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Mibefradil Digoxin Cardoxin® Increased digoxin exposure Details Mibefradil Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Mibefradil Felodipine Plendil® Severe bradycardia and hypotension Details Mibefradil Lefamulin Xenleta Increased lefamulin exposure and an increased risk of lefamulin-related adverse reactions Details Mibefradil Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Mibefradil Morphine Injection Astramorph® PF Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Mibefradil Nifedipine Adalat® Severe bradycardia and hypotension Details Mibefradil Nisoldipine Sular Severe bradycardia and hypotension Details

Minor

Mibefradil Fluvastatin Lescol An increased risk of myopathy and/or rhabdomyolysis Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.