Midazolam Injection

276 interactions 915 cited references
Also sold as: Nayzilam Versed® Injection
About Midazolam Injection

Midazolam injection is used before medical procedures and surgery to cause drowsiness, relieve anxiety, and prevent any memory of the event. It is also sometimes given as part of the anesthesia during surgery to produce a loss of consciousness. Midazolam injection is also used to cause a state of decreased consciousnes… Read the full Midazolam Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Midazolam Injection Amprenavir An increased risk of midazolam toxicity (excessive sedation, confusion) Details Midazolam Injection Atazanavir Reyataz Increased midazolam exposure Details Midazolam Injection Boceprevir Increased midazolam concentrations Details Midazolam Injection Cobicistat Tybost Increased midazolam plasma concentrations and increased risk for serious adverse effects including, prolonged or increased sedatio... Details Midazolam Injection Darunavir Increased midazolam exposure and an increased risk of prolonged sedation or respiratory depression Details Midazolam Injection Delavirdine Rescriptor® Increased midazolam concentrations Details Midazolam Injection Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Midazolam Injection Flumazenil Increased risk of serious adverse effects in patients who are physically dependent on benzodiazepines, including seizures Details Midazolam Injection Fosamprenavir Lexiva An increased risk of midazolam toxicity (excessive sedation, confusion, respiratory depression) Details Midazolam Injection Indinavir Increased midazolam plasma concentrations Details Midazolam Injection Isocarboxazid Marplan An increased risk of CNS depression Details Midazolam Injection Itraconazole Sporanox Increased midazolam exposure and an increased risk of midazolam-related adverse effects (respiratory depression) Details Midazolam Injection Ketoconazole Extina Increased midazolam exposure and potentially increased midazolam toxicity (excessive sedation and prolonged hypnotic effects) Details Midazolam Injection Levoketoconazole Recorlev Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Midazolam Injection Lonafarnib Zokinvy Increased midazolam exposure and an increased risk of midazolam-related adverse effects Details Midazolam Injection Lopinavir Increased midazolam plasma concentrations Details Midazolam Injection Nelfinavir Viracept Increased midazolam exposure and an increase risk of prolonged sedation or respiratory depression Details Midazolam Injection Nirmatrelvir An increased risk of extreme sedation and respiratory depression Details Midazolam Injection Ritonavir Norvir An increased risk of extreme sedation and respiratory depression Details Midazolam Injection Saquinavir An increased risk of midazolam toxicity (excessive sedation, respiratory depression) Details Midazolam Injection Telaprevir Increased midazolam concentrations and risk of prolonged sedation or respiratory depression Details Midazolam Injection Tipranavir Aptivus An increased risk of extreme sedation and respiratory depression Details

Major

Midazolam Injection Adagrasib Krazati Increased CYP3A4 substrate exposure Details Midazolam Injection Alfentanil Increased risk of respiratory or CNS depression and hypotension Details Midazolam Injection Alprazolam Xanax Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Injection Amobarbital Amytal Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Injection Anileridine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Injection Apalutamide Erleada Reduced CYP3A4 substrate exposure Details Midazolam Injection Aprobarbital Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Injection Aripiprazole Abilify An increased risk of sedation and orthostatic hypotension Details Midazolam Injection Aripiprazole Lauroxil Aristada An increased risk of sedation and orthostatic hypotension Details Midazolam Injection Avacopan Tavneos Increased CYP3A4 substrate exposure Details Midazolam Injection Baclofen Fleqsuvy Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Injection Benzhydrocodone Increased risk of respiratory and CNS depression Details Midazolam Injection Bromazepam Increased risk of respiratory or cardiovascular depression Details Midazolam Injection Bromopride Potentiation of sedative effects Details Midazolam Injection Buprenorphine Belbuca An increased risk of CNS depression and respiratory depression Details Midazolam Injection Buspirone Bucapsol Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Injection Butabarbital Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Injection Butalbital Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.