Midazolam Nasal Spray

276 interactions 915 cited references

Also sold as: Nayzilam Nayzilam®

About Midazolam Nasal Spray

Midazolam nasal spray is used for emergency situations to stop cluster seizures (episodes of increased seizure activity) in adults and children 12 years of age and older who are taking other medications to treat epilepsy (seizures). Midazolam is in a class of medications called benzodiazepines. It works by calming abno… Read the full Midazolam Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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22 Contraindicated 197 Major 52 Moderate 5 Minor

All (276) Contraindicated (22) Major (197) Moderate (52) Minor (5)

Moderate

Midazolam Nasal Spray Aprepitant Aponvie Increased midazolam exposure Details Midazolam Nasal Spray Armodafinil Nuvigil Decreased midazolam effectiveness Details Midazolam Nasal Spray Artemether Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Midazolam Nasal Spray Brimonidine Alphagan An increased risk of CNS depression Details Midazolam Nasal Spray Carbachol Isopto Carbachol An increased risk of CNS depression Details Midazolam Nasal Spray Cimetidine Tagamet Midazolam toxicity (CNS depression, sedation, dizziness, ataxia, weakness, decreased cognition or motor performance) Details Midazolam Nasal Spray Clonidine Duraclon An increased risk of sedation and somnolence Details Midazolam Nasal Spray Crizotinib Xalkori Increased midazolam exposure Details Midazolam Nasal Spray Cyclosporine Atopica Decreased midazolam clearance and increased midazolam plasma concentrations Details Midazolam Nasal Spray Dalfopristin An increased risk of midazolam toxicity (excessive sedation, confusion) Details Midazolam Nasal Spray Dong Quai Excessive muscle relaxation and central nervous system depression Details Midazolam Nasal Spray Echinacea Alterations in midazolam effectiveness Details Midazolam Nasal Spray Fluvoxamine Elevated serum midazolam concentrations Details Midazolam Nasal Spray Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Midazolam Nasal Spray Fosaprepitant Emend Injection Increased midazolam exposure Details Midazolam Nasal Spray Fosphenytoin Cerebyx Decreased efficacy of midazolam Details Midazolam Nasal Spray Ganaxolone Ztalmy An increased risk of somnolence and sedation Details Midazolam Nasal Spray Ginkgo Increased or decreased midazolam plasma concentrations Details Midazolam Nasal Spray Goldenseal Increased plasma concentrations of midazolam Details Midazolam Nasal Spray Haloperidol An increased risk of CNS depression Details Midazolam Nasal Spray Halothane Potentiation of anesthetic effects of halothane Details Midazolam Nasal Spray Hydrastis Increased plasma concentrations of midazolam Details Midazolam Nasal Spray Josamycin Increased benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details Midazolam Nasal Spray Kava Increased central nervous system depression Details Midazolam Nasal Spray Laropiprant Increased exposure of active metabolite of midazolam Details Midazolam Nasal Spray Mavacamten Camzyos Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Midazolam Nasal Spray Mitotane Lysodren Decreased midazolam exposure Details Midazolam Nasal Spray Omeprazole Gastrobim Benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details Midazolam Nasal Spray Paclitaxel Abraxane Altered (increased/reduced) PACLitaxel exposure, reduced PACLitaxel exposure and an increased PACLitaxel-related adverse reactions... Details Midazolam Nasal Spray Paclitaxel Protein-Bound Altered (increased/reduced) PACLitaxel exposure, reduced PACLitaxel exposure and an increased PACLitaxel-related adverse reactions... Details Midazolam Nasal Spray Passionflower Additive CNS depression Details Midazolam Nasal Spray Pazopanib Votrient Increased midazolam plasma concentrations Details Midazolam Nasal Spray Phenytoin Dilantin Decreased efficacy of midazolam Details Midazolam Nasal Spray Pioglitazone Actos Decreased plasma concentrations of midazolam Details Midazolam Nasal Spray Quinupristin An increased risk of midazolam toxicity (excessive sedation, confusion) Details Midazolam Nasal Spray Ranitidine Increased midazolam bioavailability Details Midazolam Nasal Spray Rifampin Rifadin Decreased plasma concentrations of midazolam Details Midazolam Nasal Spray Rifapentine Priftin Reduced diazepam plasma concentrations and effectiveness Details Midazolam Nasal Spray Rilzabrutinib Wayrilz Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Midazolam Nasal Spray Roxithromycin Increased benzodiazepine toxicity (CNS depression, ataxia, lethargy) Details

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