Midazolam Nasal Spray

276 interactions 915 cited references

Also sold as: Nayzilam Nayzilam®

About Midazolam Nasal Spray

Midazolam nasal spray is used for emergency situations to stop cluster seizures (episodes of increased seizure activity) in adults and children 12 years of age and older who are taking other medications to treat epilepsy (seizures). Midazolam is in a class of medications called benzodiazepines. It works by calming abno… Read the full Midazolam Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ritonavir Saquinavir Telaprevir Tipranavir Amprenavir Atazanavir

22 Contraindicated 197 Major 52 Moderate 5 Minor

All (276) Contraindicated (22) Major (197) Moderate (52) Minor (5)

Major

Midazolam Nasal Spray Adagrasib Krazati Increased CYP3A4 substrate exposure Details Midazolam Nasal Spray Alfentanil Increased risk of respiratory or CNS depression and hypotension Details Midazolam Nasal Spray Alprazolam Xanax Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Amobarbital Amytal Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Anileridine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Apalutamide Erleada Reduced CYP3A4 substrate exposure Details Midazolam Nasal Spray Aprobarbital Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Aripiprazole Abilify An increased risk of sedation and orthostatic hypotension Details Midazolam Nasal Spray Aripiprazole Lauroxil Aristada An increased risk of sedation and orthostatic hypotension Details Midazolam Nasal Spray Avacopan Tavneos Increased CYP3A4 substrate exposure Details Midazolam Nasal Spray Baclofen Fleqsuvy Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Benzhydrocodone Increased risk of respiratory and CNS depression Details Midazolam Nasal Spray Bromazepam Increased risk of respiratory or cardiovascular depression Details Midazolam Nasal Spray Bromopride Potentiation of sedative effects Details Midazolam Nasal Spray Buprenorphine Belbuca An increased risk of CNS depression and respiratory depression Details Midazolam Nasal Spray Buspirone Bucapsol Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Butabarbital Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Butalbital Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Butorphanol Butorphic Increased risk of respiratory and CNS depression Details Midazolam Nasal Spray Calcifediol Rayaldee Altered serum levels of calcifediol Details Midazolam Nasal Spray Calcium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Midazolam Nasal Spray Cannabidiol Epidiolex Increased risk of CNS depression and an increased risk of sedation and somnolence Details Midazolam Nasal Spray Cannabis An increased risk of CNS depression Details Midazolam Nasal Spray Carbamazepine Carbatrol Reduced midazolam exposure and reduced efficacy of midazolam, an increased risk of respiratory depression, profound sedation, hypo... Details Midazolam Nasal Spray Carbidopa Lodosyn An increased risk of CNS depression Details Midazolam Nasal Spray Carbinoxamine Carbzah An increased risk of CNS depression Details Midazolam Nasal Spray Carisoprodol Soma Additive respiratory depression Details Midazolam Nasal Spray Ceritinib Zykadia Increased CYP3A substrate exposure Details Midazolam Nasal Spray Cetirizine Aller-Tec Increased risk of CNS depression Details Midazolam Nasal Spray Chloral Hydrate Additive respiratory depression Details Midazolam Nasal Spray Chlordiazepoxide Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Chlorpromazine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Chlorzoxazone Lorzone Additive respiratory depression Details Midazolam Nasal Spray Ciprofloxacin Increased midazolam exposure and increased risk for prolonged sedation Details Midazolam Nasal Spray Clarithromycin Biaxin Increased midazolam exposure and an increased risk of midazolam-related adverse events Details Midazolam Nasal Spray Clobazam Onfi Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Clomipramine Anafranil An increased risk of CNS depression Details Midazolam Nasal Spray Clonazepam Klonopin Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Clorazepate Tranxene Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.