Midazolam Nasal Spray

Name: Midazolam Nasal Spray Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

276 interactions 915 cited references

Also sold as: Nayzilam Nayzilam®

About Midazolam Nasal Spray

Midazolam nasal spray is used for emergency situations to stop cluster seizures (episodes of increased seizure activity) in adults and children 12 years of age and older who are taking other medications to treat epilepsy (seizures). Midazolam is in a class of medications called benzodiazepines. It works by calming abno… Read the full Midazolam Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ritonavir Saquinavir Telaprevir Tipranavir Amprenavir Atazanavir

22 Contraindicated 197 Major 52 Moderate 5 Minor

All (276) Contraindicated (22) Major (197) Moderate (52) Minor (5)

Minor

Midazolam Nasal Spray Atorvastatin Atorvaliq Prolonged midazolam efficacy Details Midazolam Nasal Spray Magnolia Increased central nervous system depression Details Midazolam Nasal Spray Probenecid Enhanced CNS depressive effects of midazolam Details Midazolam Nasal Spray Skullcap Increased central nervous system depression Details Midazolam Nasal Spray Tan-Shen Increased risk of central nervous system depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.