Midazolam Nasal Spray

276 interactions 915 cited references

Also sold as: Nayzilam Nayzilam®

About Midazolam Nasal Spray

Midazolam nasal spray is used for emergency situations to stop cluster seizures (episodes of increased seizure activity) in adults and children 12 years of age and older who are taking other medications to treat epilepsy (seizures). Midazolam is in a class of medications called benzodiazepines. It works by calming abno… Read the full Midazolam Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ritonavir Saquinavir Telaprevir Tipranavir Amprenavir Atazanavir

22 Contraindicated 197 Major 52 Moderate 5 Minor

All (276) Contraindicated (22) Major (197) Moderate (52) Minor (5)

Major

Midazolam Nasal Spray Dronedarone Multaq Increased midazolam exposure and increased risk for prolonged sedation Details Midazolam Nasal Spray Droperidol An increased risk of CNS depression Details Midazolam Nasal Spray Duvelisib Copiktra Increased exposure of sensitive CYP3A4 substrates and risk of toxicity Details Midazolam Nasal Spray Elagolix Orilissa Decreased midazolam exposure Details Midazolam Nasal Spray Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Midazolam Nasal Spray Erythromycin Erythrocin Stearate Increased midazolam exposure and an increased risk of midazolam-related adverse reactions Details Midazolam Nasal Spray Esketamine Spravato Increased risk of sedation Details Midazolam Nasal Spray Estazolam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Eszopiclone Lunesta Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Ethchlorvynol Additive respiratory depression Details Midazolam Nasal Spray Ethylmorphine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Fedratinib Inrebic Increased CYP3A4 substrate exposure Details Midazolam Nasal Spray Fentanyl Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Midazolam Nasal Spray Fexinidazole An increased CYP3A4 substrate exposure Details Midazolam Nasal Spray Flibanserin Addyi Increased risk of CNS depression Details Midazolam Nasal Spray Fluconazole Diflucan Increased midazolam exposure and potential midazolam toxicity (excessive sedation and prolonged hypnotic effects) Details Midazolam Nasal Spray Flunitrazepam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Flurazepam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Foscarbidopa An increased risk of CNS depression Details Midazolam Nasal Spray Foslevodopa An increased risk of CNS depression Details Midazolam Nasal Spray Fosnetupitant Increased exposure of CYP3A4 substrate Details Midazolam Nasal Spray Fospropofol Additive cardiorespiratory effects Details Midazolam Nasal Spray Gabapentin Gabarone An increased risk of respiratory depression and sedation Details Midazolam Nasal Spray Gabapentin Enacarbil Horizant An increased risk of respiratory depression Details Midazolam Nasal Spray Halazepam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Hydrocodone Hysingla Increased risk of respiratory and CNS depression Details Midazolam Nasal Spray Hydromorphone Dilaudid Increased risk of respiratory and CNS depression Details Midazolam Nasal Spray Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Midazolam Nasal Spray Hydroxyzine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Idelalisib Zydelig Increased exposure of CYP3A substrate Details Midazolam Nasal Spray Imatinib Gleevec Increased midazolam exposure and increased risk for prolonged sedation Details Midazolam Nasal Spray Isavuconazole Increased midazolam exposure Details Midazolam Nasal Spray Isavuconazonium Cresemba Increased midazolam exposure Details Midazolam Nasal Spray Ivacaftor Kalydeco Increased benzodiazepine exposure and an increased risk of benzodiazepine-related adverse effects Details Midazolam Nasal Spray Ivosidenib Tibsovo Reduced exposure of sensitive CYP3A4 substrates and risk of loss of efficacy Details Midazolam Nasal Spray Ketamine Increased risk of respiratory and CNS depression Details Midazolam Nasal Spray Ketazolam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Ketobemidone Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Kratom Increased CYP3A substrate exposure and an increased risk of CNS depression Details Midazolam Nasal Spray Lacosamide Motpoly An increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.