Midazolam Nasal Spray

276 interactions 915 cited references

Also sold as: Nayzilam Nayzilam®

About Midazolam Nasal Spray

Midazolam nasal spray is used for emergency situations to stop cluster seizures (episodes of increased seizure activity) in adults and children 12 years of age and older who are taking other medications to treat epilepsy (seizures). Midazolam is in a class of medications called benzodiazepines. It works by calming abno… Read the full Midazolam Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ritonavir Saquinavir Telaprevir Tipranavir Amprenavir Atazanavir

22 Contraindicated 197 Major 52 Moderate 5 Minor

All (276) Contraindicated (22) Major (197) Moderate (52) Minor (5)

Major

Midazolam Nasal Spray Gabapentin Gabarone An increased risk of respiratory depression and sedation Details Midazolam Nasal Spray Gabapentin Enacarbil Horizant An increased risk of respiratory depression Details Midazolam Nasal Spray Halazepam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Hydrocodone Hysingla Increased risk of respiratory and CNS depression Details Midazolam Nasal Spray Hydromorphone Dilaudid Increased risk of respiratory and CNS depression Details Midazolam Nasal Spray Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Midazolam Nasal Spray Hydroxyzine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Idelalisib Zydelig Increased exposure of CYP3A substrate Details Midazolam Nasal Spray Imatinib Gleevec Increased midazolam exposure and increased risk for prolonged sedation Details Midazolam Nasal Spray Isavuconazole Increased midazolam exposure Details Midazolam Nasal Spray Isavuconazonium Cresemba Increased midazolam exposure Details Midazolam Nasal Spray Ivacaftor Kalydeco Increased benzodiazepine exposure and an increased risk of benzodiazepine-related adverse effects Details Midazolam Nasal Spray Ivosidenib Tibsovo Reduced exposure of sensitive CYP3A4 substrates and risk of loss of efficacy Details Midazolam Nasal Spray Ketamine Increased risk of respiratory and CNS depression Details Midazolam Nasal Spray Ketazolam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Ketobemidone Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Kratom Increased CYP3A substrate exposure and an increased risk of CNS depression Details Midazolam Nasal Spray Lacosamide Motpoly An increased risk of CNS depression Details Midazolam Nasal Spray Larotrectinib Increased sensitive CYP3A4 substrate exposure and increase in the incidence or severity of adverse reactions Details Midazolam Nasal Spray Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Midazolam Nasal Spray Lemborexant Dayvigo An increased risk of CNS depression and potential next-day somnolence Details Midazolam Nasal Spray Lenacapavir Sunlenca Increased midazolam exposure Details Midazolam Nasal Spray Letermovir Prevymis Increased midazolam exposure and increased risk for prolonged sedation Details Midazolam Nasal Spray Levocetirizine Xyzal Increased risk of CNS depression Details Midazolam Nasal Spray Levodopa Inbrija An increased risk of CNS depression Details Midazolam Nasal Spray Levorphanol Xyvona An increased risk of respiratory and CNS depression Details Midazolam Nasal Spray Lofexidine Increased risk of CNS depressant effects Details Midazolam Nasal Spray Lorazepam Ativan Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Loxapine Adasuve Potentiation of impaired cognitive function and motor skills and an increased risk of respiratory depression, hypotension, profoun... Details Midazolam Nasal Spray Lumacaftor Reduced exposure to CYP3A substrate Details Midazolam Nasal Spray Magnesium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Midazolam Nasal Spray Meclizine Antivert An increase in CNS or respiratory depression Details Midazolam Nasal Spray Meperidine Demerol Increased risk of respiratory depression, profound sedation, hypotension, coma and death Details Midazolam Nasal Spray Mephenesin Additive respiratory depression Details Midazolam Nasal Spray Mephobarbital Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Meprobamate Additive respiratory depression Details Midazolam Nasal Spray Meptazinol Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Mesoridazine An increased risk of CNS depression Details Midazolam Nasal Spray Metaxalone Skelaxin Additive respiratory depression Details Midazolam Nasal Spray Methadone Diskets Increased risk of respiratory and CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.