Midazolam Nasal Spray

276 interactions 915 cited references

Also sold as: Nayzilam Nayzilam®

About Midazolam Nasal Spray

Midazolam nasal spray is used for emergency situations to stop cluster seizures (episodes of increased seizure activity) in adults and children 12 years of age and older who are taking other medications to treat epilepsy (seizures). Midazolam is in a class of medications called benzodiazepines. It works by calming abno… Read the full Midazolam Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ritonavir Saquinavir Telaprevir Tipranavir Amprenavir Atazanavir

22 Contraindicated 197 Major 52 Moderate 5 Minor

All (276) Contraindicated (22) Major (197) Moderate (52) Minor (5)

Major

Midazolam Nasal Spray Methocarbamol Atmeksi Additive respiratory depression Details Midazolam Nasal Spray Methohexital Brevital Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Methotrimeprazine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Metoclopramide Increased risk of CNS depression Details Midazolam Nasal Spray Mifepristone Korlym Increased CYP3A4 substrate exposure Details Midazolam Nasal Spray Mirtazapine Mirataz Increased risk of somnolence Details Midazolam Nasal Spray Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Midazolam Nasal Spray Morphine Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Midazolam Nasal Spray Morphine Sulfate Liposome Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Midazolam Nasal Spray Nalbuphine Increased risk of respiratory and CNS depression Details Midazolam Nasal Spray Nefazodone Increased exposure of midazolam and risk of sedation Details Midazolam Nasal Spray Netupitant Increased exposure of CYP3A4 substrate Details Midazolam Nasal Spray Nicomorphine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Nilotinib Increased midazolam exposure Details Midazolam Nasal Spray Nitrazepam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Olanzapine Potentiation of excessive sedation and cardiorespiratory depression Details Midazolam Nasal Spray Oliceridine Olinvyk An increased risk of hypotension, respiratory depression, profound sedation, coma and death Details Midazolam Nasal Spray Olutasidenib Rezlidhia Reduced sensitive CYP3A substrate exposure Details Midazolam Nasal Spray Omaveloxolone Skyclarys Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Midazolam Nasal Spray Opium Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Opium Alkaloids Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Orlistat Alli Reduced efficacy of anticonvulsant Details Midazolam Nasal Spray Orphenadrine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Oxazepam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Oxycodone Oxaydo An increased risk of respiratory depression, profound sedation, coma and death Details Midazolam Nasal Spray Oxymorphone Increased risk of respiratory and CNS depression Details Midazolam Nasal Spray Paliperidone Erzofri An increased risk of CNS depression Details Midazolam Nasal Spray Papaveretum Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Paregoric Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Pentazocine Increased risk of respiratory and CNS depression Details Midazolam Nasal Spray Pentobarbital Fatal-Plus Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Perampanel FYCOMPA Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Periciazine Risk of enhanced CNS depression Details Midazolam Nasal Spray Phenobarbital Fidoquel An increased risk of CNS depression, reduced midazolam exposure and reduced efficacy of midazolam Details Midazolam Nasal Spray Pimozide An increased risk of CNS depression and an increased risk of seizure Details Midazolam Nasal Spray Piritramide Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Pirtobrutinib Jaypirca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-related adverse effects Details Midazolam Nasal Spray Posaconazole Noxafil Increased midazolam exposure Details Midazolam Nasal Spray Potassium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Midazolam Nasal Spray Prazepam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.