Midazolam Nasal Spray

276 interactions 915 cited references

Also sold as: Nayzilam Nayzilam®

About Midazolam Nasal Spray

Midazolam nasal spray is used for emergency situations to stop cluster seizures (episodes of increased seizure activity) in adults and children 12 years of age and older who are taking other medications to treat epilepsy (seizures). Midazolam is in a class of medications called benzodiazepines. It works by calming abno… Read the full Midazolam Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ritonavir Saquinavir Telaprevir Tipranavir Amprenavir Atazanavir

22 Contraindicated 197 Major 52 Moderate 5 Minor

All (276) Contraindicated (22) Major (197) Moderate (52) Minor (5)

Major

Midazolam Nasal Spray Pregabalin Bonqat An increased risk of respiratory depression Details Midazolam Nasal Spray Primidone Mysoline An increased risk of CNS depression, reduced midazolam exposure and reduced efficacy of midazolam Details Midazolam Nasal Spray Promethazine Phenadoz Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Propofol Diprivan Additive cardiorespiratory effects Details Midazolam Nasal Spray Quazepam Doral Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Ramelteon Rozerem Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Ranolazine Aspruzyo Increased exposure of CYP3A4 substrate Details Midazolam Nasal Spray Relacorilant Lifyorli Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse reactions Details Midazolam Nasal Spray Remifentanil Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Remimazolam Byfavo Increased risk of profound sedation, respiratory depression, coma, and death Details Midazolam Nasal Spray Ritlecitinib Litfulo Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Midazolam Nasal Spray Ropeginterferon Alfa-2B-Njft Besremi Increased risk of sedation Details Midazolam Nasal Spray Scopolamine Pamine Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Midazolam Nasal Spray Secobarbital Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Simeprevir Olysio® Increased midazolam exposure Details Midazolam Nasal Spray Sodium Oxybate Lumryz An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Midazolam Nasal Spray Sufentanil Dsuvia Reduced pulmonary arterial pressure, increased risk for hypotension, profound sedation, respiratory depression, coma, and death Details Midazolam Nasal Spray Suzetrigine Journavx Reduced sensitive CYP3A substrate exposure and reduced efficacy of sensitive CYP3A substrate Details Midazolam Nasal Spray Tapentadol Nucynta An increased risk of CNS depression and an increased risk of respiratory depression, profound sedation, coma and death. Details Midazolam Nasal Spray Tazemetostat Tazverik Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Midazolam Nasal Spray Temazepam Restoril Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Thiopental Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Thioridazine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Tilidine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Tizanidine Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Topiramate Eprontia Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Tramadol ConZip Increased risk of CNS depression Details Midazolam Nasal Spray Tranylcypromine Parnate An increased risk of CNS depression Details Midazolam Nasal Spray Trazodone Raldesy Increased risk of CNS depression Details Midazolam Nasal Spray Triazolam Halcion Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Trofinetide Daybue Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related toxicities Details Midazolam Nasal Spray Voriconazole Vfend Increase midazolam exposure and potential midazolam toxicity (excessive sedation and prolonged hypnotic effects) Details Midazolam Nasal Spray Zaleplon Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Ziprasidone Geodon An increased risk of CNS depression Details Midazolam Nasal Spray Zolpidem Ambien An increased risk of CNS depression, complex sleep behaviors and respiratory depression Details Midazolam Nasal Spray Zopiclone Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Midazolam Nasal Spray Zuranolone Zurzuvae An increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.