Midodrine

Name: Midodrine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

9 interactions

Also sold as: Orvaten® Proamatine®

About Midodrine

Midodrine is used to treat orthostatic hypotension (sudden fall in blood pressure that occurs when a person assumes a standing position). Midodrine is in a class of medications called alpha-adrenergic agonists. It works by causing blood vessels to tighten, which increases blood pressure. Read the full Midodrine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Droxidopa Levothyroxine Linezolid Injection Liothyronine Methylergonovine Olodaterol Oral Inhalation

6 Major 3 Moderate

All (9) Major (6) Moderate (3)

Major

Midodrine Droxidopa Northera Increased risk of hypertension Details Midodrine Levothyroxine Ermeza Increased risk of hypertension Details Midodrine Linezolid Injection Zyvox Increased exposure to midodrine Details Midodrine Liothyronine Cytomel Increased risk of hypertension Details Midodrine Methylergonovine Methergine Additive hypertensive effects Details Midodrine Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details

Moderate

Midodrine Digoxin Cardoxin® Enhanced or precipitated bradycardia, AV block, or arrhythmia Details Midodrine Doxazosin Cardura Decreased midodrine effectiveness Details Midodrine Fludrocortisone Acetate Florinef® Supine hypertension Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.