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Midodrine

Midodrine is an oral tablet medicine used to treat symptomatic orthostatic hypotension, a drop in blood pressure on standing that causes symptoms like dizziness.

Brand names OrvatenProamatine
Drug class Alpha-adrenergic Agonist
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 52 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026 🚨Recall on record
Midodrine at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Midodrine treats symptomatic orthostatic hypotension (blood pressure that drops when you stand, causing dizziness) by tightening small arteries and veins. On the market since about 1996 and available generically, it is a main option once support stockings, fluids and lifestyle changes fall short. Most people tolerate it reasonably well, though scalp tingling or itching, goosebumps and needing to urinate more often are common. The boxed warning is markedly high blood pressure when lying down, so take it only during upright daytime hours, report a pounding headache or blurred vision, keep up with lying-down blood pressure checks, and continue it only if it clearly helps.

Clinical pearls

  • Take the last dose by early evening, well before bedtime, so it is not still raising your pressure once you lie down.
  • Skip cold and sinus products containing pseudoephedrine or phenylephrine, which add to midodrine and can push blood pressure dangerously high.
  • If you also take fludrocortisone or salt tablets, expect closer lying-down blood pressure checks, since together they raise that risk.
  • Tell your prescriber if you take digoxin, because the combination can slow the heartbeat or disturb its rhythm.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Midodrine can cause a marked rise in blood pressure when you are lying down. Because of this, it is for people whose lives are considerably impaired despite standard care.

It was approved based on its ability to raise standing blood pressure. Its clinical benefit, mainly an improved ability to carry out daily activities, has not been verified. Your doctor should watch your blood pressure, and you should report any severe headache, blurred vision or pounding in the head.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asTablet
Earliest FDA record1996
Companies listing it with the FDA32
FDA label last updatedSep 29, 2022
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Midodrine, written from its FDA label.

What Midodrine is used for

▾

Midodrine tablets have one supported use.

  • Symptomatic orthostatic hypotension, a drop in blood pressure on standing that causes symptoms. This applies to Midodrine Hydrochloride and Midodrine HCl oral tablets.
  • It is for people considerably impaired despite standard care such as support stockings, fluid expansion and lifestyle changes.

How Midodrine works

▾

Midodrine is a prodrug. Your body turns it into desglymidodrine, which activates alpha-1 receptors on the small arteries and veins. This tightens the blood vessels and raises blood pressure.

It does not stimulate the heart's beta receptors, and it does not enter the brain easily. It has no significant effect on pulse rate in people with autonomic failure.

Midodrine dosage

▾

Midodrine tablets are taken by mouth, usually three times daily during the daytime when you need to be upright.

  • Doses are spaced about 4 hours apart, or 3 hours if needed for symptoms, but not closer.
  • Take the last dose no later than 6 P.M., and not within 4 hours of bedtime.
  • Food does not affect how much active drug your body gets.

Follow your prescriber's instructions and the label.

Dosing details from the FDA-approved label

From the Midodrine prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Symptomatic orthostatic hypotension (general recommended dosing)
    • 10 mg, 3 times daily, during the daytime hours when the patient needs to be upright
    • Suggested schedule at approximately 4-hour intervals: shortly before or upon arising in the morning, midday and late afternoon (not later than 6 P.M.)
    • Doses may be given in 3-hour intervals, if required, to control symptoms, but not more frequently
    • Maximum: Single doses as high as 20 mg have been given, but severe and persistent systolic supine hypertension occurs at a high rate (about 45%) at this dose. Total daily doses greater than 30 mg have been tolerated by some patients, but safety and usefulness have not been studied systematically or established.
    • Should not be given after the evening meal or less than 4 hours before bedtime; continue only in patients who attain symptomatic improvement during initial treatment.
  • Patients with abnormal renal function
    • Initiate treatment using 2.5 mg doses
    • Dosing should be cautious because desglymidodrine is excreted renally; not systematically studied.
  • Children
    • Dosing in children has not been adequately studied
  • Patients 65 or older vs. younger than 65, and males vs. females
    • Dose modifications are not necessary
    • Blood levels of midodrine and desglymidodrine were similar between these groups.
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION The recommended dose of midodrine hydrochloride tablets is 10 mg, 3 times daily. Dosing should take place during the daytime hours when the patient needs to be upright, pursuing the activities of daily living. A suggested dosing schedule of approximately 4-hour intervals is as follows: shortly before, or upon arising in the morning, midday and late afternoon (not later than 6 P.M.). Doses may be given in 3-hour intervals, if required, to control symptoms, but not more frequently. Single doses as high as 20 mg have been given to patients, but severe and persistent systolic supine hypertension occurs at a high rate (about 45%) at this dose. In order to reduce the potential for supine hypertension during sleep, midodrine hydrochloride tablets should not be given after the evening meal or less than 4 hours before bedtime. Total daily doses greater than 30 mg have been tolerated by some patients, but their safety and usefulness have not been studied systematically or established. Because of the risk of supine hypertension, midodrine hydrochloride tablets should be continued only in patients who appear to attain symptomatic improvement during initial treatment. The supine and standing blood pressure should be monitored regularly, and the administration of midodrine hydrochloride tablets should be stopped if supine blood pressure increases excessively. Because desglymidodrine is excreted renally, dosing in patients with abnormal renal function should be cautious; although this has not been systematically studied, it is recommended that treatment of these patients be initiated using 2.5 mg doses. Dosing in children has not been adequately studied. Blood levels of midodrine and desglymidodrine were similar when comparing levels in patients 65 or older vs. younger than 65 and when comparing males vs. females, suggesting dose modifications for these groups are not necessary.

Read the full Dosage and Administration section on DailyMed →

Midodrine side effects

▾

Most side effects come from midodrine acting on receptors in the skin, hair follicles and bladder.

Common side effects

  • Tingling or “pins and needles” feeling, mainly on the scalp
  • Itching, mainly on the scalp
  • Goosebumps
  • Chills
  • Urinary urgency, frequency or trouble emptying the bladder
  • High blood pressure when lying down or sitting
  • Rash
  • Urinary urgency, frequency or retention

When to get medical help

  • Call your doctor if you have a pounding headache, blurred vision or a feeling of pressure in the head, which can signal very high blood pressure when lying down.
  • Get medical help if you have signs of stroke or other serious blood pressure problems, since uncontrolled high blood pressure raises the risk of stroke.
  • Call your doctor if you have trouble passing urine.
  • Tell your prescriber if you feel no real improvement in your symptoms, because treatment should continue only if it is helping.
  • Seek urgent help after a suspected overdose.

Less often, people had headache, a feeling of pressure in the head, facial flushing, confusion, dry mouth or nervousness. Call your doctor about severe high blood pressure signs or trouble urinating.

Midodrine warnings and precautions

▾
  • Supine hypertension is the biggest risk. It can raise the risk of cardiovascular events, particularly stroke.
  • Blood pressure should be monitored lying down and sitting.
  • Use is not recommended if lying-down systolic pressure is above 180 mmHg.
  • Treatment should be stopped if lying-down pressure rises too much.
  • The benefit in daily activities has not been established, so continue only if symptoms clearly improve.

Midodrine interactions

▾

Several medicines can raise blood pressure further or change midodrine's effects.

  • Phenylephrine, pseudoephedrine, ephedrine, dihydroergotamine, thyroid hormones and droxidopa add to the rise in blood pressure.
  • Cardiac glycosides such as digoxin may cause a slow heart rate, heart block or arrhythmia.
  • MAO inhibitors and linezolid should be avoided.
  • Fludrocortisone may increase lying-down blood pressure, so it needs careful monitoring.
  • Prazosin, terazosin and doxazosin can block midodrine's effects.

Interactions listed in the FDA-approved label

From the Midodrine prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Cardiac glycosides: May enhance or precipitate bradycardia, A.V. block or arrhythmia.
  • Drugs that increase blood pressure (phenylephrine, pseudoephedrine, ephedrine, dihydroergotamine, thyroid hormones, droxidopa): The risk of hypertension increases with concomitant administration. Avoid concomitant use; if it cannot be avoided, monitor blood pressure closely.
  • Salt-retaining steroid therapy (fludrocortisone acetate): Has been used concomitantly, with or without salt supplementation; potential for supine hypertension. Carefully monitor for supine hypertension; it may be minimized by reducing the fludrocortisone acetate dose or decreasing salt intake prior to initiation of midodrine.
  • Alpha-adrenergic blocking agents (prazosin, terazosin, doxazosin): Can antagonize the effects of midodrine hydrochloride tablets.
Read the label’s full interactions text

Drug Interactions When administered concomitantly with midodrine hydrochloride tablets, cardiac glycosides may enhance or precipitate bradycardia, A.V. block or arrhythmia. The risk of hypertension increases with concomitant administration of drugs that increase blood pressure (phenylephrine, pseudoephedrine, ephedrine, dihydroergotamine, thyroid hormones, or droxidopa). Avoid concomitant use of drugs that increase blood pressure. If concomitant use cannot be avoided, monitor blood pressure closely. Avoid use of MAO inhibitors or linezolid with midodrine. Midodrine hydrochloride tablets have been used in patients concomitantly treated with salt-retaining steroid therapy (i.e., fludrocortisone acetate), with or without salt supplementation. The potential for supine hypertension should be carefully monitored in these patients and may be minimized by either reducing the dose of fludrocortisone acetate or decreasing the salt intake prior to initiation of treatment with midodrine hydrochloride tablets. Alpha-adrenergic blocking agents, such as prazosin, terazosin, and doxazosin, can antagonize the effects of midodrine hydrochloride tablets.

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿17 supplements and herbs with documented Midodrine interactions, ranked by severity Check Midodrine against a supplement or herb →

Before taking Midodrine

▾
  • Do not use with severe organic heart disease, acute kidney disease, urinary retention, pheochromocytoma or thyrotoxicosis.
  • Do not use with persistent, excessive high blood pressure when lying down.
  • With abnormal kidney function, treatment starts at a low dose and proceeds cautiously.
  • Dosing in children has not been adequately studied.
  • No dose changes are suggested based on age 65 or older or on sex.

Midodrine overdose

▾

Overdose symptoms can include high blood pressure, goosebumps, a feeling of coldness and urinary retention. Reported cases also involved a slow heart rate and drowsiness or unresponsiveness. Treatment is supportive, and may include stomach emptying and medicines that block alpha receptors. Seek emergency help right away.

What Midodrine does in the body

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Midodrine raises standing, sitting and lying blood pressure. Standing systolic pressure rises about 15 to 30 mmHg an hour after a 10 mg dose, with some effect lasting 2 to 3 hours. It has no clinically significant effect on pulse rate in people with autonomic failure.

How your body processes Midodrine

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Midodrine is absorbed quickly and converted to its active form, desglymidodrine. Midodrine peaks in about half an hour. The active form peaks in 1 to 2 hours and has a half-life of about 3 to 4 hours. Food does not affect it. It is cleared mainly by the kidneys, and it is removed by dialysis.

How to store Midodrine

▾

Store at 20°C to 25°C (68°F to 77°F); excursions permitted from 15°C to 30°C (59°F to 86°F) . Dispense in a tight, light-resistant container .

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

17

Supplements & herbs that interact with Midodrine

17 supplements and herbal products have documented interactions with Midodrine in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 1
  • Moderate · 7
  • Minor · 9
ACTIVATED CHARCOAL Major COFFEE CHARCOAL Moderate EUROPEAN MANDRAKE Moderate GLUCOMANNAN Moderate GUAR GUM Moderate GUM ARABIC Moderate SLIPPERY ELM Moderate TRAGACANTH Moderate +9 more
Every supplement checked against Midodrine — ranked by severity The full interaction hub: 1 major · 7 moderate · 9 minor · every one linked to its full report. Check Midodrine against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Midodrine: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Midodrine — the kind of thing our pharmacy team would talk through with you at the counter.

What is midodrine for?

▾
It treats symptomatic orthostatic hypotension, where your blood pressure drops when you stand and you feel dizzy or light-headed. It is meant for people who still struggle after trying things like support stockings, fluids and lifestyle changes.

When should I take it during the day?

▾
Take it during the daytime when you will be upright, usually spaced a few hours apart. Your last dose should be no later than 6 P.M. and at least 4 hours before bed. This helps lower the risk of high blood pressure while you sleep.

What side effects are normal?

▾
Tingling or itching of the scalp, goosebumps, chills and needing to urinate more often or urgently are common. These come from how the drug acts on the body's receptors. Call your doctor if you cannot pass urine, or if you get a bad headache or blurred vision.

Why does my blood pressure need to be checked lying down?

▾
Midodrine can raise your blood pressure a lot when you are lying flat. That can raise your risk of stroke if it goes uncontrolled. Regular checks help your doctor decide whether to continue or stop.

Can I take it with cold medicines or other prescriptions?

▾
Check with me first. Decongestants like pseudoephedrine and phenylephrine can push your blood pressure higher. Digoxin, MAO inhibitors, linezolid and alpha-blockers like prazosin can also cause problems or weaken its effect.

Is Midodrine available over the counter?

▾
No. Midodrine is a prescription medicine: every Midodrine product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Midodrine first available?

▾
The earliest FDA record we hold for Midodrine is from 1996: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Midodrine was first used.

Who makes Midodrine?

▾
32 companies currently list Midodrine products in the FDA's NDC Directory, including Bryant Ranch Prepack, Major Pharmaceuticals, NorthStar Rx LLC. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Midodrine on HelloPharmacist

📊Midodrine supplement interactions17 checked — ranked by severity 🌿Drug & Supplement CheckerMidodrine vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Midodrine NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Midodrine Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Midodrine forms and strengths (how it comes)

Midodrine is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Tablet

By mouth
How this form is used
What it may be used for
  • Midodrine Hydrochloride tablets are used to treat symptomatic orthostatic hypotension.
  • Midodrine HCl tablets are used for symptomatic orthostatic hypotension in people impaired despite standard care.
Important instructions
  • Midodrine Hydrochloride tablets are taken by mouth during daytime hours when you need to be upright.
  • Midodrine HCl tablets should not be given after the evening meal or less than 4 hours before bedtime.
  • Midodrine Hydrochloride tablets are continued only if symptoms improve significantly, with regular blood pressure monitoring.
Available strengths 3 strengths
2.5 mg 5 mg 10 mg
195 FDA-listed product records ⓘ

Midodrine on the U.S. market: products, makers and brands

How Midodrine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

32 companies list 109 Midodrine product records with the FDA, mostly as tablet; the earliest marketing or approval year on record is 1996. Brand names on the directory include Orvaten, Proamatine; the rest are generics.

1
Dose forms ⓘ
32
Labelers (makers, repackagers, distributors)
2
Brand names
109
FDA-listed product records ⓘ
1996
Earliest FDA record ⓘ

Also listed with the FDA, not a patient dose form: Powder (14) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack14%
Major Pharmaceuticals6%
NorthStar Rx LLC6%
Cardinal Health 107, LLC4%
Advagen Pharma Limited3%
Alembic Pharmaceuticals Inc.3%
Other makers66%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Midodrine is used (Medicaid data)

A general measure of how commonly Midodrine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Midodrine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

328,426
Medicaid prescriptions filled (Q1–Q4 2025)
$7.3M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Midodrine prescribed? Of the 1,601 medications we measure, Midodrine ranks #313 by Medicaid prescriptions — more than 80% of them.

Where Midodrine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #313 of 1,601
#308 Nitroglycerin Spray 340,741 Rx #309 Nitroglycerin 340,741 Rx #310 Olmesartan 340,022 Rx #311 Fluvoxamine 332,998 Rx #312 Ubrogepant 329,850 Rx #313 Midodrine 328,426 Rx #314 Dexamethasone / Neomyc... 327,807 Rx #315 Prochlorperazine 323,439 Rx #316 Lansoprazole 322,236 Rx #317 Fluocinolone 320,047 Rx #318 Bevacizumab Injection 309,873 Rx

Utilization by Midodrine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 5 mg oral tablet is the most-dispensed Midodrine product — about 50% of these Medicaid prescriptions.

midodrine hydrochloride 5 MG Oral Tablet Most dispensed

162,630 Medicaid prescriptions (Q1–Q4 2025) 50% of Midodrine prescriptions shown $3.3M gross reimbursement (before rebates) ≈ $20 per prescription (gross)

Summed across the 20 of 68 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 993470

midodrine hydrochloride 10 MG Oral Tablet

110,668 Medicaid prescriptions (Q1–Q4 2025) 34% of Midodrine prescriptions shown $3.1M gross reimbursement (before rebates) ≈ $28 per prescription (gross)

Summed across the 14 of 55 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 993462

midodrine hydrochloride 2.5 MG Oral Tablet

55,128 Medicaid prescriptions (Q1–Q4 2025) 17% of Midodrine prescriptions shown $871,006 gross reimbursement (before rebates) ≈ $16 per prescription (gross)

Summed across the 12 of 56 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 993466

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Midodrine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 46 of 179 listed Midodrine NDCs with Medicaid activity.

Compare Midodrine products

A representative set of FDA-listed product records for Midodrine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 109 of 109 products — FDA National Drug Code Directory. See every product, package size and price: browse all 109 Midodrine NDCs →

Midodrine recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list one Midodrine recall since July 2021. It is still ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Ongoing Class II Feb 17, 2026 · The Harvard Drug Group LLC
Defective container; inadequately sealed blister packaging.
  • Midodrine Hydrochloride Tablets, USP, 5 mg, 50 Tablets (5 x 10 blister packs), Rx only, Packaged and Distributed by: Major Pharmaceuticals, Indianapolis, IN 46268 USA, NDC 0904-6818-06. Lots: Lot # N02640, Exp Date: 08/2027 FDA record D-0383-2026 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Midodrine RxCUI 6963 1 dose form · 3 strengths

Look up RxCUI 6963 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Midodrine costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Tablet · Oral 5 mg $0.111 per tablet NDC details & price history
Tablet · Oral 2.5 mg $0.074 per tablet NDC details & price history
Tablet · Oral 10 mg $0.151 per tablet NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Midodrine brand names

Midodrine is sold under 2 brand names in the FDA directory — Orvaten, Proamatine. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Orvaten Proamatine

Who makes Midodrine: manufacturers and labelers

32 companies list Midodrine products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, Major Pharmaceuticals, NorthStar Rx LLC. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Bryant Ranch Prepack 15 Major Pharmaceuticals 6 NorthStar Rx LLC 6 Cardinal Health 107, LLC 4 Advagen Pharma Limited 3 Alembic Pharmaceuticals Inc. 3 Alembic Pharmaceuticals Limited 3 American Health Packaging 3 Apotex Corp 3 Aurobindo Pharma Limited 3 AvKARE 3 AvPAK 3 Avet Pharmaceuticals Inc. 3 Endo USA, Inc. 3 First Nation Group, LLC 3 Golden State Medical Supply, Inc. 3 Lifestar Pharma LLC 3 Mylan Pharmaceuticals Inc. 3 NCS HealthCare of KY, LLC dba Vangard Labs 3 Novugen Pharma (USA) LLC 3 PD-Rx Pharmaceuticals, Inc. 3 Proficient Rx LP 3 Rising Pharma Holdings, Inc. 3 TruPharma, LLC 3

…and 8 more on the FDA NDC directory.

Midodrine drug class (RxNorm)

Midodrine belongs to the alpha-Adrenergic Agonist class.

Pharmacologic class alpha-Adrenergic Agonist
Drug family (ATC) Adrenergic and dopaminergic agents
How it works Adrenergic alpha-Agonists

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Midodrine page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Sep 29, 2022
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Midodrine.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Midodrine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
52
Finished products in the current FDA directory
109
Companies listing them (makers, repackagers, distributors)
32
FDA labeler codes behind them ⓘ
34
Linked representative label ⓘ
Mylan Pharmaceuticals Inc.
Linked label effective
Sep 29, 2022
Composite sections available
18
Linked SPL Set ID
32fad00b-7e7b-4d35-9e8b-fdc979fdb88e
Linked SPL Document ID
e92f278e-0a58-49e3-8fc0-3a16b8474d3b
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Mylan Pharmaceuticals Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →