Milnacipran

68 interactions 5 explained in plain English
Also sold as: Savella
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Milnacipran Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Milnacipran Amitriptyline Elavil Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Milnacipran Sertraline Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Milnacipran Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Milnacipran Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Milnacipran Aspirin Acuprin® An increased risk of bleeding Details Milnacipran Aspirin Rectal Aspirin An increased risk of bleeding Details Milnacipran Azathioprine Azasan An increased risk of hepatotoxicity Details Milnacipran Betrixaban Bevyxxa® An increased risk of bleeding Details Milnacipran Anagrelide Agrylin An increased risk of bleeding Details Milnacipran Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Milnacipran Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Milnacipran Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Milnacipran Clopidogrel Plavix An increased risk of bleeding Details Milnacipran Dabigatran Pradaxa® An increased risk of bleeding Details Milnacipran Dabigatran Etexilate An increased risk of bleeding Details Milnacipran Dalteparin Injection Fragmin An increased risk of bleeding Details Milnacipran Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Milnacipran Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Milnacipran Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Milnacipran Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Milnacipran Digoxin Cardoxin® Potentiation of adverse hemodynamic effects Details Milnacipran Dipyridamole Permole® An increased risk of bleeding Details Milnacipran Dolasetron Anzemet Increased risk of serotonin syndrome Details Milnacipran Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Milnacipran Edoxaban Savaysa Increased risk of bleeding Details Milnacipran Enoxaparin Lovenox An increased risk of bleeding Details Milnacipran Enoxaparin Injection Lovenox An increased risk of bleeding Details Milnacipran Epoprostenol Flolan An increased risk of bleeding Details Milnacipran Etodolac Lodine An increased risk of bleeding Details Milnacipran Fenoprofen Fenopron An increased risk of bleeding Details Milnacipran Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Milnacipran Flurbiprofen Ansaid An increased risk of bleeding Details Milnacipran Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Milnacipran Fondaparinux Arixtra An increased risk of bleeding Details Milnacipran Fondaparinux Injection Arixtra An increased risk of bleeding Details Milnacipran Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.