Minocycline Topical

94 interactions 271 cited references

Also sold as: Amzeeq Amzeeq® Zilxi Zilxi®

About Minocycline Topical

Minocycline topical (Amzeeq) is used to treat certain types of acne in adults and children 9 years of age and older. Minocyclinetopical (Zilxi) is used to treat inflammatory lesions of rosacea in adults. Minocycline is in a class of medications called tetracycline antibiotics. It works to treat acne by killing the bact… Read the full Minocycline Topical drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acitretin Acenocoumarol Warfarin Tretinoin Tinzaparin Temocillin

1 Contraindicated 72 Major 21 Moderate

All (94) Contraindicated (1) Major (72) Moderate (21)

Contraindicated

Minocycline Topical Acitretin Soriatane® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

Major

Minocycline Topical Acenocoumarol An increased risk of bleeding Details Minocycline Topical Amoxicillin Amoxi Drop Decreased antibacterial effectiveness Details Minocycline Topical Ampicillin Amcill® Decreased antibacterial effectiveness Details Minocycline Topical Apixaban Eliquis An increased risk of bleeding Details Minocycline Topical Ardeparin An increased risk of bleeding Details Minocycline Topical Argatroban An increased risk of bleeding Details Minocycline Topical Atazanavir Reyataz Decreased atazanavir exposure and plasma concentrations Details Minocycline Topical Azathioprine Azasan An increased risk of hepatotoxicity Details Minocycline Topical Bacampicillin Decreased antibacterial effectiveness Details Minocycline Topical Bemiparin An increased risk of bleeding Details Minocycline Topical Betrixaban Bevyxxa® An increased risk of bleeding Details Minocycline Topical Bexarotene Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Minocycline Topical Bivalirudin Angiomax An increased risk of bleeding Details Minocycline Topical Certoparin An increased risk of bleeding Details Minocycline Topical Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Minocycline Topical Cloxacillin Decreased antibacterial effectiveness Details Minocycline Topical Dabigatran Etexilate An increased risk of bleeding Details Minocycline Topical Dalteparin Fragmin An increased risk of bleeding Details Minocycline Topical Danaparoid An increased risk of bleeding Details Minocycline Topical Desirudin Iprivask An increased risk of bleeding Details Minocycline Topical Desogestrel Decreased contraceptive efficacy Details Minocycline Topical Dicloxacillin Decreased antibacterial effectiveness Details Minocycline Topical Dienogest Decreased contraceptive efficacy Details Minocycline Topical Digoxin Cardoxin® Increased digoxin levels and digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Minocycline Topical Drospirenone Decreased contraceptive efficacy Details Minocycline Topical Edoxaban Savaysa An increased risk of bleeding Details Minocycline Topical Enoxaparin Lovenox An increased risk of bleeding Details Minocycline Topical Estradiol Delestrogen Decreased contraceptive efficacy Details Minocycline Topical Ethinyl Estradiol Decreased contraceptive efficacy Details Minocycline Topical Ethynodiol Decreased contraceptive efficacy Details Minocycline Topical Etretinate An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Minocycline Topical Exenatide Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Minocycline Topical Fondaparinux Arixtra An increased risk of bleeding Details Minocycline Topical Gestodene Decreased contraceptive efficacy Details Minocycline Topical Heparin An increased risk of bleeding Details Minocycline Topical Isotretinoin Absorica An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Minocycline Topical Lepirudin An increased risk of bleeding Details Minocycline Topical Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Minocycline Topical Levonorgestrel After banger Decreased contraceptive efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.