Drug Interaction Report

Mometasone and Insulin Lispro, Recombinant: Interaction Details

A pharmacist-reviewed analysis of the Mometasone and Insulin Lispro, Recombinant interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Mometasone

Asmanex Nasonex Propel Sinuva
+

Insulin Lispro, Recombinant

Admelog Humalog Lyumjev
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
LinkedIn
Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 45 documented Mometasone interactions, 18 are rated moderate — including this one.
Onset
unspecified
Evidence
theoretical
Severity
Moderate

What happens

May decrease blood glucose lowering effect of insulin lispro

Interaction Deep Dive

Concurrent use of corticosteroids and insulin lispro may decrease the blood glucose lowering effect of insulin lispro. Dose adjustments and increase frequency of glucose monitoring may be required123.

Why it happens (mechanism)

Unknown

Common questions

Can I take Mometasone and Insulin Lispro, Recombinant together?

May decrease blood glucose lowering effect of insulin lispro Always confirm with your pharmacist or prescriber before making any change.

How serious is the Mometasone and Insulin Lispro, Recombinant interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Mometasone or Insulin Lispro, Recombinant need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (3)

  1. Product Information: LYUMJEV(TM) subcutaneous, intravenous injection, insulin lispro-aabc subcutaneous, intravenous injection. Eli Lilly and Company (per FDA), Indianapolis, IN, 2020. DailyMed
  2. Product Information: HUMALOG(R) subcutaneous injection, intravenous injection, insulin lispro subcutaneous injection, intravenous injection. Lilly USA LLC (per FDA), Indianapolis, IN, 2019. DailyMed
  3. Product Information: ADMELOG(R) subcutaneous injection, intravenous injection, insulin lispro subcutaneous injection, intravenous injection. sanofi-aventis US LLC (per FDA), Bridgewater, NJ, 2019. DailyMed
Was this write-up helpful?
Mometasone

Keep reading about Mometasone

All Mometasone interactions (45) Mometasone drug information
Also serious with: Mifepristone Desmopressin Desmopressin Nasal Atazanavir
Insulin Lispro, Recombinant

Keep reading about Insulin Lispro, Recombinant

All Insulin Lispro, Recombinant interactions (128)
Also serious with: Ofloxacin Ophthalmic Gemifloxacin Orlistat Moxifloxacin Injection
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Mometasone + Activated Charcoal Grapefruit St. John's Wort Acacia Rigidula Adrafinil African Wild Potato American Elder Astaxanthin + 133 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

Check another combination

Our instant two-drug interaction checker is almost here.

Coming soon

The instant two-drug checker is on its way.

In the meantime, browse the directory below to look up any drug and see its documented interactions.

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.