Mometasone and Olodaterol: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Mometasone
Olodaterol
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of hypokalemia
Interaction Deep Dive
Concomitant use of olodaterol with corticosteroids may potentiate any hypokalemic effect of olodaterol. Clinically notable reduction in serum potassium or changes in blood glucose were infrequent during clinical studies with long-term administration of olodaterol1.
Why it happens (mechanism)
Potentiated hypokalemic effects
Literature reports
1 report — tap to read
a) Clinically notable reduction in serum potassium or changes in blood glucose were infrequent during clinical studies with long-term administration of olodaterol 1.
Common questions
Can I take Mometasone and Olodaterol together?
An increased risk of hypokalemia Always confirm with your pharmacist or prescriber before making any change.
How serious is the Mometasone and Olodaterol interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Mometasone or Olodaterol need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: STRIVERDI® RESPIMAT® inhalation spray, olodaterol inhalation spray. Boehringer Ingelheim Pharmaceuticals Inc (per DailyMed), Ridgefield, CT, 2025. DailyMed
Keep reading about Mometasone
Keep reading about Olodaterol
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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