Morphine Injection

437 interactions 767 cited references

Also sold as: Astramorph® PF Duramorph Duramorph® Infumorph Infumorph® Kadian Mitigo MS Contin

About Morphine Injection

Morphine injection is used to relieve moderate to severe pain. Morphine is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. Read the full Morphine Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Samidorphan Safinamide Rasagiline Phenelzine Ozanimod Procarbazine

12 Contraindicated 409 Major 16 Moderate

All (437) Contraindicated (12) Major (409) Moderate (16)

Major

Morphine Injection Clopamide Reduced efficacy of diuretics Details Morphine Injection Clopidogrel Plavix Reduced efficacy of clopidogrel Details Morphine Injection Clorazepate Tranxene Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Cloxazolam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Clozapine Clozaril Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of profound sedation, respirat... Details Morphine Injection Cobicistat Tybost Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Cocaine Goprelto Increased risk of serotonin syndrome Details Morphine Injection Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Conivaptan Vaprisol Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Cyclobenzaprine Amrix Increased risk of respiratory and CNS depression, increased risk of serotonin syndrome and an increased risk of urinary retention,... Details Morphine Injection Cyclopenthiazide Reduced efficacy of diuretics Details Morphine Injection Cyclopentolate Cyclogyl Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Cyclosporine Atopica Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Cyclothiazide Reduced efficacy of diuretics Details Morphine Injection Cyproheptadine Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of CNS depression Details Morphine Injection Daclatasvir Daklinza® Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Dantrolene Dantrium Increased degree of respiratory depression Details Morphine Injection Daridorexant An increased risk CNS depression Details Morphine Injection Darifenacin Enablex Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Delorazepam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Desipramine Norpramin Increased risk of urinary retention, severe constipation, paralytic ileus and an increased risk of serotonin syndrome Details Morphine Injection Desvenlafaxine Pristiq Increased risk of serotonin syndrome Details Morphine Injection Dexmedetomidine Dexased Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Dextroamphetamine Dexedrine Increased risk of serotonin syndrome Details Morphine Injection Dextromethorphan Delsym Increased risk of serotonin syndrome Details Morphine Injection Dezocine Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Morphine Injection Diacetylmorphine Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Diazepam Diastat Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Diazoxide Proglycem Reduced efficacy of diuretics Details Morphine Injection Dibenzepin Increased risk of serotonin syndrome Details Morphine Injection Dichloralphenazone Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Dicyclomine Bentyl Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Difenoxin Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Dihydrocodeine Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Diltiazem Cardizem Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Dimenhydrinate Airmit Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Diphenhydramine Banophen Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of profound sedation, respirat... Details Morphine Injection Diphenoxylate Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Dolasetron Anzemet Increased risk of serotonin syndrome Details Morphine Injection Donepezil Adlarity Reduced seizure threshold Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.