Morphine Injection

437 interactions 767 cited references
Also sold as: Astramorph® PF Duramorph Duramorph® Infumorph Infumorph® Kadian Mitigo MS Contin
About Morphine Injection

Morphine injection is used to relieve moderate to severe pain. Morphine is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. Read the full Morphine Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Samidorphan Safinamide Rasagiline Phenelzine Ozanimod Procarbazine
12 Contraindicated 409 Major 16 Moderate
All (437) Contraindicated (12) Major (409) Moderate (16)

Contraindicated

Morphine Injection Isocarboxazid Marplan Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Morphine Injection Linezolid Zyvox Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Morphine Injection Methylene Blue Provayblue Increased risk of the profound sedation, respiratory depression, hypotension, coma and an increased risk of serotonin syndrome Details Morphine Injection Naltrexone ReVia Precipitation of opioid withdrawal symptoms; decreased opioid effectiveness Details Morphine Injection Ozanimod Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Morphine Injection Phenelzine Nardil Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Morphine Injection Procarbazine Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Morphine Injection Rasagiline Azilect Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Morphine Injection Safinamide Xadago Increased risk of serotonin syndrome Details Morphine Injection Samidorphan Decreased opioid efficacy and precipitation of opioid withdrawal Details Morphine Injection Selegiline Anipryl Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Morphine Injection Tranylcypromine Parnate Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.