Morphine Injection

437 interactions 767 cited references

Also sold as: Astramorph® PF Duramorph Duramorph® Infumorph Infumorph® Kadian Mitigo MS Contin

About Morphine Injection

Morphine injection is used to relieve moderate to severe pain. Morphine is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. Read the full Morphine Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Samidorphan Safinamide Rasagiline Phenelzine Ozanimod Procarbazine

12 Contraindicated 409 Major 16 Moderate

All (437) Contraindicated (12) Major (409) Moderate (16)

Contraindicated

Morphine Injection Isocarboxazid Marplan Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Morphine Injection Linezolid Zyvox Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Morphine Injection Methylene Blue Provayblue Increased risk of the profound sedation, respiratory depression, hypotension, coma and an increased risk of serotonin syndrome Details Morphine Injection Naltrexone ReVia Precipitation of opioid withdrawal symptoms; decreased opioid effectiveness Details Morphine Injection Ozanimod Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Morphine Injection Phenelzine Nardil Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Morphine Injection Procarbazine Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Morphine Injection Rasagiline Azilect Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Morphine Injection Safinamide Xadago Increased risk of serotonin syndrome Details Morphine Injection Samidorphan Decreased opioid efficacy and precipitation of opioid withdrawal Details Morphine Injection Selegiline Anipryl Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Morphine Injection Tranylcypromine Parnate Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details

Major

Morphine Injection Abrocitinib Cibinqo Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Acepromazine PROMACE Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Aclidinium Tudorza Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Adagrasib Krazati Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Alfentanil Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Almotriptan Increased risk of serotonin syndrome Details Morphine Injection Alogliptin Nesina Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Alprazolam Xanax Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Alvimopan Entereg Decreased opioid efficacy and precipitation of opioid withdrawal Details Morphine Injection Amantadine Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Amifampridine Increased risk of seizures Details Morphine Injection Amiloride Reduced efficacy of diuretics Details Morphine Injection Amineptine Increased risk of serotonin syndrome Details Morphine Injection Amiodarone Nexterone Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Amitriptyline Elavil Increased risk of urinary retention, severe constipation, paralytic ileus and an increased risk of serotonin syndrome Details Morphine Injection Amitriptylinoxide Increased risk of serotonin syndrome Details Morphine Injection Amobarbital Amytal Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Amoxapine Increased risk of urinary retention, severe constipation, paralytic ileus and an increased risk of serotonin syndrome Details Morphine Injection Amphetamine Dexedrine Increased risk of serotonin syndrome Details Morphine Injection Anileridine Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Aripiprazole Abilify Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Aripiprazole Lauroxil Aristada Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Asenapine Saphris Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Asunaprevir Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Atorvastatin Atorvaliq Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Atropine Atropen Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Azithromycin AzaSite Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Baclofen Fleqsuvy Increased risk of profound sedation, hypotension, coma and respiratory depression Details

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