Morphine Injection

437 interactions 767 cited references

Also sold as: Astramorph® PF Duramorph Duramorph® Infumorph Infumorph® Kadian Mitigo MS Contin

About Morphine Injection

Morphine injection is used to relieve moderate to severe pain. Morphine is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. Read the full Morphine Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Samidorphan Safinamide Rasagiline Phenelzine Ozanimod Procarbazine

12 Contraindicated 409 Major 16 Moderate

All (437) Contraindicated (12) Major (409) Moderate (16)

Major

Morphine Injection Belladonna Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Bemetizide Reduced efficacy of diuretics Details Morphine Injection Bendroflumethiazide Reduced efficacy of diuretics Details Morphine Injection Benperidol Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Bentazepam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Benzhydrocodone Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Benzphetamine Increased risk of serotonin syndrome Details Morphine Injection Benzthiazide Reduced efficacy of diuretics Details Morphine Injection Benztropine Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Berotralstat Orladeyo Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Biperiden Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Boceprevir Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Bromazepam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Bromopride Potentiation of sedative effects Details Morphine Injection Brompheniramine Respa-BR Increased risk of urinary retention, severe constipation, paralytic ileus and an increased risk of serotonin syndrome Details Morphine Injection Bumetanide Bumex Reduced efficacy of diuretics Details Morphine Injection Buprenorphine Belbuca Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Morphine Injection Bupropion Aplenzin Increased risk of seizures Details Morphine Injection Buspirone Bucapsol Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Butabarbital Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Butalbital An increased risk of CNS depression Details Morphine Injection Butorphanol Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Morphine Injection Calcium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Morphine Injection Canagliflozin Invokana Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Cannabidiol Epidiolex Increased risk of CNS depression and an increased risk of sedation and somnolence Details Morphine Injection Cannabis An increased risk of CNS depression Details Morphine Injection Canrenoate Reduced efficacy of diuretics Details Morphine Injection Canrenone Reduced efficacy of diuretics Details Morphine Injection Capmatinib Tabrecta Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Captopril Capoten® Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Carbamazepine Carbatrol Increased risk of serotonin syndrome and an increased risk of CNS depression Details Morphine Injection Carbidopa Lodosyn An increased risk of CNS depression Details Morphine Injection Carbinoxamine Carbzah Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of profound sedation, respirat... Details Morphine Injection Carisoprodol Soma Increased risk of urinary retention, severe constipation, and paralytic ileus, an increased risk of profound sedation, hypotension... Details Morphine Injection Carphenazine Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Carvedilol Coreg Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Cetirizine Aller-Tec Increased risk of CNS depression Details Morphine Injection Chloral Hydrate Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Chlordiazepoxide Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Chlorothiazide Diuril Reduced efficacy of diuretics Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.