Morphine Injection

437 interactions 767 cited references

Also sold as: Astramorph® PF Duramorph Duramorph® Infumorph Infumorph® Kadian Mitigo MS Contin

About Morphine Injection

Morphine injection is used to relieve moderate to severe pain. Morphine is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. Read the full Morphine Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Samidorphan Safinamide Rasagiline Phenelzine Ozanimod Procarbazine

12 Contraindicated 409 Major 16 Moderate

All (437) Contraindicated (12) Major (409) Moderate (16)

Major

Morphine Injection Doxepin Prudoxin An increased risk of urinary retention, severe constipation, paralytic ileus, an increased risk of serotonin syndrome and an incre... Details Morphine Injection Doxylamine Aldex AN Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Dronedarone Multaq Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Droperidol Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Duloxetine Increased risk of serotonin syndrome Details Morphine Injection Elacestrant Orserdu Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Elagolix Orilissa Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Eletriptan Relpax Increased risk of serotonin syndrome Details Morphine Injection Eliglustat Cerdelga Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Enasidenib Idhifa Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Enflurane Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Entrectinib Rozlytrek Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Enzalutamide Xtandi Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Eplerenone Inspra Reduced efficacy of diuretics Details Morphine Injection Erythromycin Erythrocin Stearate Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Escitalopram Lexapro Increased risk of serotonin syndrome Details Morphine Injection Esketamine Spravato Increased risk of sedation Details Morphine Injection Estazolam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Eszopiclone Lunesta Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Ethacrynic Acid Edecrin Reduced efficacy of diuretics Details Morphine Injection Ethchlorvynol Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Ethinyl Estradiol Reduced morphine exposure Details Morphine Injection Ethopropazine Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Ethylmorphine Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Etozolin Reduced efficacy of diuretics Details Morphine Injection Felodipine Plendil® Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Fenfluramine An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Morphine Injection Fentanyl Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Fesoterodine Toviaz Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Flavoxate Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Flibanserin Addyi Increased risk of profound sedation, respiratory depression, hypotension, coma, increased morphine exposure and an increased risk... Details Morphine Injection Flunitrazepam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Fluoxetine RECONCILE Increased risk of serotonin syndrome Details Morphine Injection Fluphenazine Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of profound sedation, respirat... Details Morphine Injection Flurazepam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Fluspirilene Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Fluvoxamine Increased morphine exposure, increased risk of morphine-related adverse effects (hypotension, respiratory depression, profound sed... Details Morphine Injection Foscarbidopa An increased risk of CNS depression Details Morphine Injection Foslevodopa An increased risk of CNS depression Details Morphine Injection Fospropofol Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.