Morphine Injection

437 interactions 767 cited references

Also sold as: Astramorph® PF Duramorph Duramorph® Infumorph Infumorph® Kadian Mitigo MS Contin

About Morphine Injection

Morphine injection is used to relieve moderate to severe pain. Morphine is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. Read the full Morphine Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Samidorphan Safinamide Rasagiline Phenelzine Ozanimod Procarbazine

12 Contraindicated 409 Major 16 Moderate

All (437) Contraindicated (12) Major (409) Moderate (16)

Major

Morphine Injection Fostamatinib Tavalisse Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Frovatriptan Frova Increased risk of serotonin syndrome Details Morphine Injection Furosemide Disal Reduced efficacy of diuretics Details Morphine Injection Gabapentin Gabarone An increased risk of serious and/or fatal respiratory depression and sedation Details Morphine Injection Gabapentin Enacarbil Horizant An increased risk of respiratory depression Details Morphine Injection Gepirone Exxua An increased risk of serotonin syndrome Details Morphine Injection Glecaprevir Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Glycopyrrolate Cuvposa Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Glycopyrronium Tosylate Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Granisetron Increased risk of serotonin syndrome Details Morphine Injection Halazepam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Haloperidol Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Halothane Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Hexobarbital Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Homatropine Homatropaire Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Hydrochlorothiazide Inzirqo Reduced efficacy of diuretics Details Morphine Injection Hydrocodone Hysingla Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Hydroflumethiazide Reduced efficacy of diuretics Details Morphine Injection Hydromorphone Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Hydroxychloroquine Plaquenil An increased risk of seizures Details Morphine Injection Hydroxytryptophan Increased risk of serotonin syndrome Details Morphine Injection Hydroxyzine Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of profound sedation, respirat... Details Morphine Injection Hyoscyamine Atropen Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Ibrexafungerp Brexafemme Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Imipramine Increased risk of urinary retention, severe constipation, paralytic ileus and an increased risk of serotonin syndrome Details Morphine Injection Indapamide Reduced efficacy of diuretics Details Morphine Injection Indinavir Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Ipratropium Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Isavuconazole Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Isavuconazonium Cresemba Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Isoflurane Fluriso Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Istradefylline Nourianz Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Itraconazole Sporanox Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Ivacaftor Kalydeco Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Ketamine Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Ketazolam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Ketobemidone Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Ketoconazole Extina Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Kratom Increased risk of CNS depression and serotonin syndrome Details Morphine Injection Lacosamide Motpoly An increased risk of CNS depression Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.