Morphine Injection

437 interactions 767 cited references

Also sold as: Astramorph® PF Duramorph Duramorph® Infumorph Infumorph® Kadian Mitigo MS Contin

About Morphine Injection

Morphine injection is used to relieve moderate to severe pain. Morphine is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. Read the full Morphine Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Samidorphan Safinamide Rasagiline Phenelzine Ozanimod Procarbazine

12 Contraindicated 409 Major 16 Moderate

All (437) Contraindicated (12) Major (409) Moderate (16)

Major

Morphine Injection Metoclopramide Increased risk of CNS depression Details Morphine Injection Metolazone Reduced efficacy of diuretics Details Morphine Injection Mibefradil Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Midazolam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Mifepristone Korlym Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Milnacipran Savella Increased risk of serotonin syndrome Details Morphine Injection Mirabegron Myrbetriq Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Mirtazapine Mirataz Increased risk of serotonin syndrome Details Morphine Injection Molindone Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Moricizine Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Nalbuphine Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Morphine Injection Nalorphine Decreased opioid efficacy and precipitation of opioid withdrawal Details Morphine Injection Naloxone Kloxxado Decreased opioid efficacy and precipitation of opioid withdrawal Details Morphine Injection Naratriptan Increased risk of serotonin syndrome Details Morphine Injection Nefazodone Increased morphine exposure, increased risk of morphine-related adverse effects (hypotension, respiratory depression, profound sed... Details Morphine Injection Nelfinavir Viracept Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Neratinib Nerlynx Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Nicomorphine Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Nifedipine Adalat® Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Nitrazepam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Nitrous Oxide Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Nordazepam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Nortriptyline Increased risk of urinary retention, severe constipation, paralytic ileus and an increased risk of serotonin syndrome Details Morphine Injection Olanzapine Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of profound sedation, respirat... Details Morphine Injection Oliceridine Olinvyk Increased risk of serotonin syndrome, an increased risk of hypotension, profound sedation, respiratory depression, coma and death Details Morphine Injection Ondansetron Increased risk of serotonin syndrome Details Morphine Injection Opipramol Increased risk of serotonin syndrome Details Morphine Injection Opium Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Opium Alkaloids Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Orphenadrine Increased risk of urinary retention, severe constipation, and paralytic ileus, an increased risk of profound sedation, hypotension... Details Morphine Injection Osimertinib Tagrisso Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Oxazepam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Oxitropium Bromide Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Oxybutynin Ditropan Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Oxycodone Oxaydo Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Oxymorphone Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Paliperidone Erzofri An increased risk of CNS depression Details Morphine Injection Palonosetron Increased risk of serotonin syndrome Details Morphine Injection Papaveretum Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Injection Paregoric Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.