Netupitant

79 interactions 8 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Netupitant Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine and morphine exposure Details Netupitant Abametapir Explained Increased exposure of CYP3A4 substrate Details Netupitant Omeprazole Gastrobim Explained Increased exposure of CYP3A4 substrate Details Netupitant Buprenorphine Belbuca Explained Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Netupitant Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Netupitant Simvastatin Flolipid Explained Increased exposure of CYP3A4 substrate Details Netupitant Acalabrutinib Calquence Increased acalabrutinib exposure and increased risk of toxicity Details Netupitant Aripiprazole Injection Abilify Increased exposure of CYP3A4 substrate Details Netupitant Avapritinib Ayvakit Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Netupitant Atorvastatin Atorvaliq Increased exposure of CYP3A4 substrate Details Netupitant Cariprazine Vraylar Explained Increased cariprazine and its major active metabolite (didesmethylcariprazine (DDCAR)) exposure Details Netupitant Alfuzosin UroXatral Increased exposure of CYP3A4 substrate Details Netupitant Amlodipine Amvaz® Increased exposure of CYP3A4 substrate Details Netupitant Avanafil Stendra Increased exposure of CYP3A4 substrate Details Netupitant Axitinib Inlyta Increased exposure of CYP3A4 substrate Details Netupitant Bedaquiline Sirturo Increased bedaquiline exposure Details Netupitant Bosutinib Bosulif Increased exposure of CYP3A4 substrate Details Netupitant Brexpiprazole Rexulti Increased brexpiprazole exposure Details Netupitant Brigatinib Alunbrig Increased brigatinib exposure Details Netupitant Budesonide Entocort Increased exposure of CYP3A4 substrate Details Netupitant Budesonide Nasal Spray Rhinocort Increased exposure of CYP3A4 substrate Details Netupitant Budesonide Oral Inhalation Pulmicort Increased exposure of CYP3A4 substrate Details Netupitant Cabozantinib Cabometyx Increased exposure of CYP3A4 substrate Details Netupitant Cabozantinib (Thyroid Cancer) Cabometyx Increased exposure of CYP3A4 substrate Details Netupitant Cobimetinib Cotellic Increased exposure of CYP3A4 substrate Details Netupitant Cyclosporine Injection Atopica Increased exposure of CYP3A4 substrate Details Netupitant Cyclosporine Ophthalmic Cequa Increased exposure of CYP3A4 substrate Details Netupitant Dasatinib Phyrago Increased exposure of CYP3A4 substrate Details Netupitant Diazepam Nasal Spray Valtoco Increased exposure of CYP3A4 substrate Details Netupitant Diazepam Rectal Diastat Increased exposure of CYP3A4 substrate Details Netupitant Dihydroergotamine Injection DHE-45® Injection Increased exposure of CYP3A4 substrate Details Netupitant Dihydroergotamine Nasal Spray Migranal Increased exposure of CYP3A4 substrate Details Netupitant Docetaxel Beizray Increased exposure to chemotherapy agent and increased risk of side effects Details Netupitant Docetaxel Injection Beizray Increased exposure to chemotherapy agent and increased risk of side effects Details Netupitant Dofetilide Tikosyn Increased exposure of CYP3A4 substrate Details Netupitant Elacestrant Orserdu Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Netupitant Encorafenib Braftovi Increased encorafenib exposure and an increased risk of encorafenib-related adverse events Details Netupitant Entrectinib Rozlytrek Increased entrectinib exposure and an increased frequency or severity of adverse reactions Details Netupitant Estradiol Delestrogen Increased exposure of CYP3A4 substrate Details Netupitant Estradiol Topical Divigel Increased exposure of CYP3A4 substrate Details

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