Nirmatrelvir

Contraindicated

Nirmatrelvir Colchicine Colcrys Explained Increased colchicine exposure and increased risk of colchicine toxicity Details Nirmatrelvir Simvastatin Flolipid Explained Increased risk of myopathy or rhabdomyolysis Details Nirmatrelvir Alfuzosin UroXatral Increased alfuzosin exposure; hypotension Details Nirmatrelvir Dihydroergotamine Injection DHE-45® Injection Increased risk of ergot toxicity Details Nirmatrelvir Dihydroergotamine Nasal Spray Migranal Increased risk of ergot toxicity Details Nirmatrelvir Finerenone Kerendia Increased finerenone exposure and increased risk of serious adverse effects (hyperkalemia, hypotension and hyponatremia) Details Nirmatrelvir Flecainide Tambocor® Increased flecainide plasma concentrations; potential for arrhythmias Details Nirmatrelvir Ivabradine Corlanor Increased ivabradine exposure and an increased risk of bradycardia or conduction disturbances Details Nirmatrelvir Ketoconazole Topical Extina® Foam Increased ketoconazole exposure, an increased nirmatrelvir/ritonavir exposure and an increased risk for QT interval prolongation Details Nirmatrelvir Lovastatin Altocor® Increased risk of myopathy or rhabdomyolysis Details Nirmatrelvir Lurasidone Latuda Serious and/or life-threatening reactions such as cardiac arrhythmias Details Nirmatrelvir Methylergonovine Methergine Increased risk of ergot toxicity Details Nirmatrelvir Midazolam Nasal Spray Nayzilam An increased risk of extreme sedation and respiratory depression Details Nirmatrelvir Midazolam Injection Nayzilam An increased risk of extreme sedation and respiratory depression Details Nirmatrelvir Naloxegol Movantik Increased naloxegol exposure and increased risk of opioid withdrawal symptoms Details

Major

Nirmatrelvir Relugolix Orgovyx Explained Increased relugolix exposure Details Nirmatrelvir Abemaciclib Verzenio Explained Increased abemaciclib plasma concentration Details Nirmatrelvir Aliskiren Tekturna Increased aliskiren exposure Details Nirmatrelvir Apixaban Eliquis Explained Increased apixaban exposure and an increased risk of bleeding Details Nirmatrelvir Aripiprazole Injection Abilify Increased ARIPiprazole or ARIPiprazole lauroxil (prodrug of ARIPiprazole) exposure Details Nirmatrelvir Atorvastatin Atorvaliq Increased risk of myopathy, including rhabdomyolysis Details Nirmatrelvir Cariprazine Vraylar Explained Increased cariprazine exposure Details Nirmatrelvir Amlodipine Amvaz® Increased calcium channel blocker exposure and an increased risk of hypotension Details Nirmatrelvir Avanafil Stendra Increased avanafil exposure Details Nirmatrelvir Bedaquiline Sirturo Increased bedaquiline exposure Details Nirmatrelvir Brexpiprazole Rexulti Increased brexpiprazole exposure Details Nirmatrelvir Budesonide Entocort Increased corticosteroid exposure Details Nirmatrelvir Budesonide Nasal Spray Rhinocort Increased corticosteroid exposure Details Nirmatrelvir Budesonide Oral Inhalation Pulmicort Increased corticosteroid exposure Details Nirmatrelvir Ciclesonide Nasal Spray Omnaris Increased corticosteroid exposure and increased risk of Cushing syndrome and adrenal suppression Details Nirmatrelvir Ciclesonide Oral Inhalation Alvesco Increased corticosteroid exposure and increased risk of Cushing syndrome and adrenal suppression Details Nirmatrelvir Clopidogrel Plavix Decreased clopidogrel efficacy Details Nirmatrelvir Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Nirmatrelvir Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Nirmatrelvir Dabigatran Pradaxa® Increased dabigatran exposure and increased risk of bleeding Details Nirmatrelvir Dabigatran Etexilate Increased dabigatran exposure and increased risk of bleeding Details Nirmatrelvir Dasatinib Phyrago Increased dasatinib exposure and an increased risk of QT interval prolongation Details Nirmatrelvir Deflazacort Emflaza Increased corticosteroid exposure Details Nirmatrelvir Dexamethasone Injection Decadron Increased dexAMETHasone exposure, reduced nirmatrelvir/ritonavir exposure and an increased risk of loss of virologic response and... Details Nirmatrelvir Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased dexAMETHasone exposure, reduced nirmatrelvir/ritonavir exposure and an increased risk of loss of virologic response and... Details